, Evolution du la durée de l'intervalle QT corrigé par la formule de Fridericia Figure 37. Evolution de la durée de l'intervalle QT corrigé par la formule de Fridericia de l'ECG au cours du développement de l'IC chez le mongrel (n=6) pendant les 42 jours de stimulation

L. De-fridericia, QTcF) augmente significativement dès J7 (271±8 vs 239±5 à J0) puis reste stable jusqu'à J35 (259±2 ms à J14 à 258±9 ms à J35)

A. J21, la FR augmente de manière significative de +27±3% (27.9±0.65 vs 22.0±0.36 % à l'état basal, p=0.0121) et revient à la valeur basale

A. J42, on observe l'absence d'effet sur la FR à l'effet max comparé à l

, Effet sur la dépolarisation et repolarisation totale (QT décomposé) de l'ECG

, Tableau 5. Effets du HMR1556 sur les sous -intervalles mesuré du QT aux différents stades de la pathologie

, Le HMR1556 augmente significativement l'intervalle QT ainsi que l'intervalle JT au 3 stades du syndrome et la durée du complexe QRS reste inchangée

, Concernant les pourcentages calculés, à l'état sain, le HMR1556 augmente de manière significatif le pourcentage de Tp-Te/QT et Tp-Te/JT (respectivement de +7.2% et 11.6%) et le JT/QT reste inchangé

A. J21, les proportions diffèrent par rapport à J0. En effet, le HMR1556 n'augmente pas les pourcentages Tp-Te/QT et Tp-Te/JT mais augmente de 3

, A J42, les pourcentages varient dans le même sens qu'à J21 avec une augmentation

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