, Evolution du la durée de l'intervalle QT corrigé par la formule de Fridericia Figure 37. Evolution de la durée de l'intervalle QT corrigé par la formule de Fridericia de l'ECG au cours du développement de l'IC chez le mongrel (n=6) pendant les 42 jours de stimulation
, QTcF) augmente significativement dès J7 (271±8 vs 239±5 à J0) puis reste stable jusqu'à J35 (259±2 ms à J14 à 258±9 ms à J35)
, la FR augmente de manière significative de +27±3% (27.9±0.65 vs 22.0±0.36 % à l'état basal, p=0.0121) et revient à la valeur basale
on observe l'absence d'effet sur la FR à l'effet max comparé à l ,
, Effet sur la dépolarisation et repolarisation totale (QT décomposé) de l'ECG
, Tableau 5. Effets du HMR1556 sur les sous -intervalles mesuré du QT aux différents stades de la pathologie
, Le HMR1556 augmente significativement l'intervalle QT ainsi que l'intervalle JT au 3 stades du syndrome et la durée du complexe QRS reste inchangée
, Concernant les pourcentages calculés, à l'état sain, le HMR1556 augmente de manière significatif le pourcentage de Tp-Te/QT et Tp-Te/JT (respectivement de +7.2% et 11.6%) et le JT/QT reste inchangé
, les proportions diffèrent par rapport à J0. En effet, le HMR1556 n'augmente pas les pourcentages Tp-Te/QT et Tp-Te/JT mais augmente de 3
, A J42, les pourcentages varient dans le même sens qu'à J21 avec une augmentation
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une des lois fondamentales en hémodynamique, dit qu'il existe une relation entre l'étirement des fibres musculaires myocardiques et leur performance contractile : plus elles s'étirent, mieux elles se contractent ,
, Donc plus le ventricule gauche (VG) est bien rempli (avec donc distension des fibres myocardiques) mieux il va se contracter. Ceci est en partie lié au fait que lorsque les fibres myocardiques s'étirent, les filaments d'actine et de myosine se rapprochent et sont dans une position optimale. Le volume de remplissage final du VG s