H. Fukumoto, B. S. Cheung, B. T. Hyman, and M. C. Irizarry, Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease, Arch Neurol, vol.59, issue.9, pp.1381-1389, 2002.

H. Fukumoto, D. L. Rosene, M. B. Moss, S. Raju, B. T. Hyman et al., Beta-secretase activity increases with aging in human, monkey, and mouse brain, Am J Pathol, vol.164, issue.2, p.719, 2004.

K. Furukawa, S. W. Barger, E. M. Blalock, and M. P. Mattson, Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein, Nature, vol.379, issue.6560, pp.74-78, 1996.

K. Furukawa, B. L. Sopher, R. E. Rydel, J. G. Begley, D. G. Pham et al., Increased activity-regulating and neuroprotective efficacy of alpha-secretase-derived secreted amyloid precursor protein conferred by a C-terminal heparin-binding domain (1996), J Neurochem, vol.67, issue.5, p.1331

N. Gakhar-koppole, P. Hundeshagen, C. Mandl, S. W. Weyer, B. Allinquant et al., Activity requires soluble amyloid precursor protein alpha to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway, Eur J Neurosci, vol.28, issue.5, pp.871-882, 2008.

K. Ghosal, D. L. Vogt, M. Liang, Y. Shen, B. T. Lamb et al., Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain, Proc Natl Acad Sci U S A, vol.106, issue.43, pp.18367-18372, 2009.

M. L. Giuffrida, F. Caraci, B. Pignataro, S. Cataldo, D. Bona et al., Betaamyloid monomers are neuroprotective, J Neurosci, vol.29, issue.34, pp.10582-10589, 2009.

C. Glabe, Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease, J Mol Neurosci, vol.17, issue.2, pp.137-182, 2001.

G. G. Glenner and C. W. Wong, Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein, Biochem Biophys Res Commun, vol.120, issue.3, pp.885-890, 1984.

A. E. González, V. C. Muñoz, V. A. Cavieres, H. A. Bustamante, V. H. Cornejo et al., , 2017.

, Autophagosomes cooperate in the degradation of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway, FASEB J, vol.31, issue.6, pp.2446-2459

Z. V. Goodger, L. Rajendran, A. Trutzel, B. M. Kohli, R. M. Nitsch et al., Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway, J Cell Sci, vol.122, pp.3703-3714, 2009.

G. K. Gouras, J. Tsai, J. Naslund, B. Vincent, M. Edgar et al., Intraneuronal Abeta42 accumulation in human brain, Am J Pathol, vol.156, issue.1, pp.15-20, 2000.

G. K. Gouras, C. G. Almeida, and R. H. Takahashi, Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease, Neurobiol Aging, vol.26, issue.9, pp.1235-1279, 2005.

C. Goutte, W. Hepler, K. M. Mickey, and J. R. Priess, aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling, Development, vol.127, issue.11, pp.2481-2492, 2000.

C. Goutte, M. Tsunozaki, V. A. Hale, and J. R. Priess, APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos, Proc Natl Acad Sci U S A, vol.99, issue.2, pp.775-784, 2002.

J. P. Greenfield, J. Tsai, G. K. Gouras, B. Hai, G. Thinakaran et al., Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides, Proc Natl Acad Sci U S A, vol.96, issue.2, pp.742-747, 1998.

J. P. Greenfield, G. K. Gouras, and H. Xu, Cellular and molecular basis of beta-amyloid precursor protein metabolism, Front Biosci, vol.3, pp.399-407, 1998.

Y. Gu, H. Misonou, T. Sato, N. Dohmae, K. Takio et al., Distinct intramembrane cleavage of the beta-amyloid precursor protein family resembling gamma-secretase-like cleavage of Notch, J Biol Chem, vol.276, issue.38, pp.35235-35238, 2001.

Y. Gu, F. Chen, N. Sanjo, T. Kawarai, H. Hasegawa et al., APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes, J Biol Chem, vol.278, issue.9, pp.7374-7380, 2003.

C. Haass, M. G. Schlossmacher, A. Y. Hung, C. Vigo-pelfrey, A. Mellon et al., Amyloid beta-peptide is produced by cultured cells during normal metabolism, Nature, vol.359, issue.6393, pp.322-325, 1992.

C. Haass, C. A. Lemere, A. Capell, M. Citron, P. Seubert et al., , 1995.

, The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway, Nat Med, vol.1, issue.12, pp.1291-1296

C. Haass, Take five-BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation (2004), EMBO J, vol.23, issue.3, pp.483-491

R. Hamid, E. Kilger, M. Willem, N. Vassallo, M. Kostka et al., Amyloid precursor protein intracellular domain modulates cellular calcium homeostasis and ATP content, J Neurochem, vol.102, issue.4, pp.1264-1275, 2007.

W. Hampe and M. Rezgaoui, The genes for the human VPS10 domain-containing receptors are large and contain many small exons, Hum Genet, vol.108, issue.6, pp.529-536, 2001.

J. A. Hardy and G. A. Higgins, Alzheimer's disease: the amyloid cascade hypothesis, Science, vol.256, issue.5054, pp.184-185, 1992.

X. He, F. Li, W. P. Chang, and J. Tang, GGA proteins mediate the recycling pathway of memapsin 2 (BACE), J Biol Chem, vol.280, issue.12, pp.11696-11703, 2005.

L. B. Hersh and D. W. Rodgers, Neprilysin and amyloid beta peptide degradation, Curr Alzheimer Res, vol.5, issue.2, pp.225-256, 2008.

G. Hermey and I. B. Riedel, Identification and characterization of SorCS, a third member of a novel receptor family, Biochem Biophys Res Commun, vol.266, issue.2, pp.347-351, 1999.

V. Herzog, G. Kirfel, C. Siemes, and A. Schmitz, Biological roles of APP in the epidermis, Eur J Cell Biol, vol.83, pp.613-637, 2004.

M. Higuchi, N. Iwata, Y. Matsuba, K. Sato, K. Sasamoto et al., 19F and 1H MRI detection of amyloid beta plaques in vivo, Nat Neurosci, vol.8, issue.4, pp.527-533, 2005.

R. M. Holsinger, C. A. Mclean, K. Beyreuther, C. L. Masters, and G. Evin, Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease, Ann Neurol, vol.51, issue.6, pp.783-786, 2002.

I. Hussain, D. Powell, D. R. Howlett, D. G. Tew, T. D. Meek et al., Identification of a novel aspartic protease (Asp 2) as beta-secretase, Mol Cell Neurosci, vol.14, issue.6, pp.419-427, 1999.

T. Iwatsubo, T. C. Saido, D. M. Mann, V. M. Lee, and J. Q. Trojanowski, Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques (1996), Am J Pathol, vol.149, issue.6, pp.1823-1830, 1996.

C. R. Jack, R. C. Petersen, Y. Xu, P. C. O'brien, G. E. Smith et al., Rates of hippocampal atrophy correlate with change in clinical status in aging and AD, Neurology, vol.55, issue.4, pp.484-489, 2000.

L. Jacobsen, P. Madsen, C. Jacobsen, M. S. Nielsen, J. Gliemann et al., Activation and functional characterization of the mosaic receptor SorLA/LRl 1, J Biol Chem, vol.276, issue.25, pp.22788-22796, 2001.

L. Jacobsen, P. Madsen, M. S. Nielsen, W. P. Geraerts, J. Gliemann et al., The sorLA cytoplasmic domain interacts with GGA1 and-2 and defines minimum requirements for GGA binding, FEBS Lett, vol.511, issue.1-3, pp.155-158, 2002.

S. Jaeger and C. U. Pietrzik, Functional role of lipoprotein receptors in Alzheimer's disease, Curr Alzheimer Res, vol.5, issue.1, pp.15-25, 2008.

R. F. Lane, S. M. Raines, J. W. Steele, M. E. Ehrlich, J. A. Lah et al., Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex, J Neurosci, vol.30, issue.39, pp.13110-13115, 2010.

J. Laurén, D. A. Gimbel, H. B. Nygaard, J. W. Gilbert, and S. M. Strittmatter, Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers, Nature, vol.457, issue.7233, pp.1128-1160, 2009.

I. Lauritzen, R. Pardossi-piquard, C. Bauer, E. Brigham, J. D. Abraham et al., The ?-secretasederived C-terminal fragment of ?APP, C99, but not A?, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus, J Neurosci, vol.32, pp.16243-1655, 2012.

I. Lauritzen, R. Pardossi-piquard, A. Bourgeois, S. Pagnotta, M. G. Biferi et al., Intraneuronal aggregation of the ?-CTF fragment of APP (C99) induces A?-independent lysosomal-autophagic pathology, Acta Neuropathol, vol.132, issue.2, pp.257-76, 2016.

J. Lee, C. Rétamai, L. Cuitino, A. Caruano-yzermans, J. E. Shin et al., Adaptor protein sorting nexin 17 regulates amyloid precursor protein trafficking and processing in the early endosomes, J Biol Chem, vol.283, issue.17, pp.11501-11508, 2008.

M. K. Lee, H. H. Slunt, L. J. Martin, G. Thinakaran, G. Kim et al., Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues, J Neurosci, vol.16, issue.23, pp.7513-7525, 1996.

E. Levy, M. D. Carman, I. J. Fernandez-madrid, M. D. Power, I. Lieberburg et al., Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type, Science, vol.248, issue.4959, pp.1124-1130, 1990.

T. Li, G. Ma, H. Cai, D. L. Price, and P. C. Wong, Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals, J Neurosci, vol.23, issue.8, pp.3272-3277, 2003.

Y. Li, C. J. Bu, and G. , Low-density lipoprotein receptor family: endocytosis and signal transduction, Mol Neurobiol, vol.23, issue.1, pp.53-67, 2001.

Y. Li, W. Zhou, Y. Tong, G. He, and W. Song, Control of APP processing and Abeta generation level by BACE1 enzymatic activity and transcription, FASEB J, vol.20, issue.2, pp.285-292, 2006.

X. Lin, G. Koelsch, S. Wu, D. Downs, A. Dashti et al., Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein, Proc Natl Acad Sci U S A, vol.97, issue.4, pp.1456-1460, 2000.

H. C. Liu, S. J. Leu, J. G. Chang, S. M. Sung, W. C. Hsu et al., The association of beta-site APP cleaving enzyme (BACE) C786G polymorphism with Alzheimer's disease, Brain Res, vol.961, issue.1, pp.88-91, 2003.

Q. Liu, C. V. Zerbinatti, J. Zhang, H. S. Hoe, B. Wang et al., Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1, Neuron, vol.56, issue.1, pp.66-78, 2007.
DOI : 10.1016/j.neuron.2007.08.008

URL : https://doi.org/10.1016/j.neuron.2007.08.008

A. Lorenzen, J. Samosh, K. Vandewark, P. H. Anborgh, C. Seah et al., Rapid and direct transport of cell surface APP to the lysosome defines a novel selective pathway, Mol Brain, vol.3, p.11, 2010.

E. Louwersheimer, A. Ramirez, C. Cruchaga, T. Becker, J. Kornhuber et al.,

, Influence of genetic variants in SORL1 gene on the manifestation of Alzheimer's disease, Neurobiol Aging, vol.36, issue.3, 2015.

D. C. Lu, S. Rabizadeh, S. Chandra, R. F. Shayya, L. M. Ellerby et al., A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor, Nat Med, vol.6, issue.4, pp.397-404, 2000.

B. Maloney and D. K. Lahiri, The Alzheimer's amyloid ?-peptide (A?) binds a specific DNA A?-interacting domain (A?ID) in the APP, BACE1, and APOE promoters in a sequence-specific manner: characterizing a new regulatory motif, Gene, vol.488, issue.1-2, pp.1-12, 2011.

P. Marambaud, K. Ancolio, E. Lopez-perez, and F. Checler, Proteasome inhibitors prevent the degradation of familial Alzheimer's disease-linked presenilin 1 and potentiate A beta 42 recovery from human cells, Mol Med, vol.4, issue.3, pp.147-57, 1998.

E. G. Marcusson and B. F. Horazdovsky, The sorting receptor for yeast vacuolar carboxypeptidase Y is encoded by the VPS10 gene, Cell, vol.77, issue.4, pp.579-586, 1994.

B. L. Martin, G. Schrader-fischer, J. Busciglio, M. Duke, P. Paganetti et al., , 1995.

, Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein, J Biol Chem, vol.270, issue.45, pp.26727-26757

M. P. Marzolo and G. Bu, Lipoprotein receptors and cholesterol in APP trafficking and proteolytic processing, implications for Alzheimer's disease, Semin Cell Dev Biol, vol.20, issue.2, pp.191-200, 2009.

C. L. Master, G. Simms, N. A. Weinman, G. Multhaup, B. L. Mcdonald et al., , 1985.

, Amyloid plaque core protein in Alzheimer disease and Down syndrome, Proc Natl Acad Sci, vol.82, pp.4245-4249

M. P. Mattson, Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives, Physiol Rev, vol.77, issue.4, pp.1081-1132, 1997.

P. May, E. Woldt, R. L. Matz, and P. Boucher, The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions, Ann Med, vol.39, issue.3, pp.219-228, 2007.

H. Meziane, J. C. Dodart, C. Mathis, S. Little, J. Clemens et al., Memoryenhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice, Proc Natl Acad Sci U S A, vol.95, issue.21, pp.12683-12691, 1998.

D. L. Miller, I. A. Papayannopoulos, J. Styles, S. A. Bobin, Y. Y. Lin et al., Peptide compositions of the cerebrovascular and senile plaque core amyloid deposits of Alzheimer's disease, Arch Biochem Biophys, vol.301, issue.1, pp.41-52, 1993.

J. S. Miners, S. Baig, J. Palmer, L. E. Palmer, P. G. Kehoe et al., Abeta-degrading enzymes in Alzheimer's disease (2008), Brain Pathol, vol.18, issue.2, pp.240-52

J. E. Morley, S. A. Farr, W. A. Banks, S. N. Johnson, K. A. Yamada et al., A physiological role for amyloid-beta protein: enhancement of learning and memory, J Alzheimers Dis, vol.19, issue.2, pp.441-450, 2010.

A. Muhammad, I. Flores, H. Zhang, R. Yu, A. Staniszewski et al., Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation, Proc Natl Acad Sci U S A, vol.105, issue.20, pp.7327-7332, 2008.

N. N. Nalivaeva, L. R. Fisk, N. D. Belyaev, and A. J. Turner, Amyloid-degrading enzymes as therapeutic targets in Alzheimer's disease, Curr Alzheimer Res, vol.5, issue.2, pp.212-236, 2008.

G. Nicolas, D. Wallon, C. Charbonnier, O. Quenez, S. Rousseau et al., , 2016.

, Screening of dementia genes by whole-exome sequencing in early-onset Alzheimer disease: input and lessons, Eur J Hum Genet, vol.24, issue.5, pp.710-716

G. Nicolas, C. Charbonnier, D. Wallon, O. Quenez, C. Bellenguez et al., SORL1 rare variants: a major risk factor for familial early-onset Alzheimer's disease. CNR-MAJ collaborators, Mol Psychiatry, vol.21, issue.6, pp.831-837, 2016.

A. Nikolaev, T. Mclaughlin, O. Leary, D. D. Tessier-lavigne, and M. , APP binds DR6 to trigger axon pruning and neuron death via distinct caspases, Nature, vol.457, issue.7232, pp.981-989, 2009.

C. Nilsberth, A. Westlind-danielsson, C. B. Eckman, M. M. Condron, K. Axelman et al., The 'Arctic' APP mutation (E693G) causes Alzheimer's disease by enhanced Abeta protofibril formation, Nat Neurosci, vol.4, issue.9, pp.887-93, 2001.

C. Nordstedt, G. L. Caporaso, J. Thyberg, S. E. Gandy, and P. Greengard, Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrincoated vesicles purified from PC12 cells, J Biol Chem, vol.268, issue.1, pp.608-612, 1993.

A. Nunomura, G. Perry, G. Aliev, K. Hirai, A. Takeda et al., Oxidative damage is the earliest event in Alzheimer disease, J Neuropathol Exp Neurol, vol.60, issue.8, pp.759-767, 2001.

A. C. Nyborg, T. B. Ladd, C. W. Zwizinski, J. J. Lah, and T. E. Golde, Sortilin, SorCSlb, and SorLA VpslOp sorting receptors, are novel gamma-secretase substrates, vol.1, p.3, 2006.

I. Ohsawa, C. Takamura, T. Morimoto, M. Ishiguro, and S. Kohsaka, Amino-terminal region of secreted form of amyloid precursor protein stimulates proliferation of neural stem cells, Eur J Neurosci, vol.11, issue.6, pp.1907-1913, 1999.

H. Okada, W. Zhang, C. Peterhoff, J. C. Hwang, R. A. Nixon et al., Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing, FASEB J, vol.24, issue.8, pp.2783-2794, 2010.

P. Osenkowski, H. Li, W. Ye, D. Li, L. Aeschbach et al., , 2009.

, Cryoelectron microscopy structure of purified gamma-secretase at 12 A resolution, J Mol Biol, vol.385, issue.2, pp.642-652

R. Pardossi-piquard, A. Petit, T. Kawarai, C. Sunyach, A. Da-costa et al., Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP, Neuron, vol.46, issue.4, pp.541-554, 2005.
URL : https://hal.archives-ouvertes.fr/hal-00170823

R. Pardossi-piquard, J. Dunys, G. Yu, S. George-hyslop, P. et al., , 2006.

, Neprilysin activity and expression are controlled by nicastrin, J Neurochem, vol.97, issue.4, pp.1052-1056

R. Pardossi-piquard and F. Checler, The physiology of the ?-amyloid precursor protein intracellular domain AICD, J Neurochem, vol.120, pp.109-124, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00724579

G. C. Peraus, C. L. Masters, and K. Beyreuther, Late compartments of amyloid precursor protein transport in SY5Y cells are involved in beta-amyloid secretion, J Neurosci, vol.17, issue.20, pp.7714-7724, 1997.

R. G. Perez, S. L. Squazzo, and E. H. Koo, Enhanced release of amyloid beta-protein from codon 670/671 "Swedish" mutant beta-amyloid precursor protein occurs in both secretory and endocytic pathways, J Biol Chem, vol.271, issue.15, pp.9100-9107, 1996.

R. G. Perez, S. Soriano, J. D. Hayes, B. Ostaszewski, W. Xia et al., Mutagenesis identifies new signals for beta-amyloid precursor protein endocytosis, turnover, and the generation of secreted fragments, including Abeta42, J Biol Chem, vol.274, issue.27, pp.18851-18856, 1999.

C. M. Petersen and M. S. Nielsen, Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography, J Biol Chem, vol.272, issue.6, pp.3599-3605, 1997.

L. D. Plant, J. P. Boyle, I. F. Smith, C. Peers, and H. A. Pearson, The production of amyloid beta peptide is a critical requirement for the viability of central neurons, J Neurosci, vol.23, issue.13, pp.5531-5535, 2003.

C. Pottier, D. Hannequin, S. Coutant, A. Rovelet-lecrux, D. Wallon et al.,

P. Gmaj-collaborators, High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease, Mol Psychiatry, vol.17, issue.9, pp.875-884, 2012.

D. Puzzo, L. Privitera, E. Leznik, M. Fà, A. Staniszewski et al., Picomolar amyloid-beta positively modulates synaptic plasticity and memory in hippocampus, J Neurosci, vol.28, issue.53, pp.14537-14582, 2008.

Y. Qi-takahara, M. Morishima-kawashima, Y. Tanimura, G. Dolios, N. Hirotani et al., Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase, J Neurosci, vol.25, issue.2, pp.436-445, 2005.

C. Reitz, R. Cheng, E. Rogaeva, J. H. Lee, S. Tokuhiro et al., Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Genetic and Environmental Risk in Alzheimer Disease 1 Consortium, Arch Neurol, vol.68, issue.1, pp.99-106, 2011.

M. Rezgaoui and G. Hermey, Identification of SorCS2, a novel member of the VPS10 domain containing receptor family, prominently expressed in the developing mouse brain, Mech Dev, vol.100, issue.2, pp.335-338, 2001.

E. Rogaeva, Y. Meng, J. H. Lee, Y. Gu, T. Kawarai et al., The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease, Nat Genet, vol.39, issue.2, pp.168-77, 2007.

A. Rovelet-lecrux, D. Hannequin, G. Raux, L. Meur, N. Laquerrière et al., APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy, Nat Genet, vol.38, issue.1, pp.24-26, 2006.

Y. Rui, J. Gu, K. Yu, H. C. Hartzell, and J. Q. Zheng, Inhibition of AMPA receptor trafficking at hippocampal synapses by beta-amyloid oligomers: the mitochondrial contribution, Mol Brain, vol.3, p.10, 2010.

T. Sato, N. Dohmae, Y. Qi, N. Kakuda, H. Misonou et al., Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein, J Biol Chem, vol.278, issue.27, pp.24294-24301, 2003.

T. Sato, T. S. Diehl, S. Narayanan, S. Funamoto, Y. Ihara et al., Active gamma-secretase complexes contain only one of each component, J Biol Chem, vol.282, issue.47, pp.33985-33993, 2007.

C. R. Scherzer, K. Offe, M. Gearing, H. D. Rees, G. Fang et al., Loss of apolipoprotein E receptor LR11 in Alzheimer disease, Arch Neurol, vol.61, issue.8, pp.1200-1205, 2004.

V. Schmidt, A. Sporbert, M. Rohe, T. Reimer, A. Rehm et al., , 2007.

, SorLA/LRl 1 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS-1, J Biol Chem, vol.282, issue.45, pp.32956-32964

G. R. Seabrook, D. W. Smith, B. J. Bowery, A. Easter, T. Reynolds et al., Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein, Neuropharmacology, vol.38, issue.3, pp.349-359, 1999.

D. J. Selkoe, Alzheimer's disease: genes, proteins, and therapy, Physiol Rev, vol.81, issue.2, pp.741-766, 2001.

P. Seubert, T. Oltersdorf, M. G. Lee, R. Barbour, C. Blomquist et al., Secretion of beta-amyloid precursor protein cleaved at the amino terminus of the beta-amyloid peptide, Nature, vol.361, issue.6409, pp.260-263, 1993.

J. Sevalle, A. Amoyel, P. Robert, M. C. Fournié-zaluski, B. Roques et al., , 2009.

, Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide, J Neurochem, vol.109, issue.1, pp.248-56

J. Sevalle, E. Ayral, J. F. Hernandez, J. Martinez, and F. Checler, Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity, J Neurochem, vol.110, issue.1, pp.275-83, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00418810

S. Shah, S. F. Lee, K. Tabuchi, Y. H. Hao, C. Yu et al., Nicastrin functions as a gamma-secretase-substrate receptor, Cell, vol.122, issue.3, pp.435-447, 2005.

S. Shah and G. Yu, sorLA: sorting out APP, Mol Interv, vol.6, issue.2, pp.74-76, 2006.

K. Shirotani, S. Tsubuki, N. Iwata, Y. Takaki, W. Harigaya et al., Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan-and phosphoramidonsensitive endopeptidases, J Biol Chem, vol.276, issue.24, pp.21895-901, 2001.

C. Siemes, T. Quast, C. Kummer, S. Wehner, G. Kirfel et al., Keratinocytes from APP/APLP2-deficient mice are impaired in proliferation, adhesion and migration in vitro, Exp Cell Res, vol.312, issue.11, pp.1939-1949, 2006.

S. Sinha, J. P. Anderson, R. Barbour, G. S. Basi, R. Caccavello et al., Purification and cloning of amyloid precursor protein beta-secretase from human brain, Nature, vol.402, issue.6761, pp.537-540, 1999.

S. A. Small, K. Kent, A. Pierce, C. Leung, M. S. Kang et al., Model-guided microarray implicates the retromer complex in Alzheimer's disease, Ann Neurol, vol.58, issue.6, pp.909-919, 2005.

S. A. Small, Retromer sorting: a pathogenic pathway in late-onset Alzheimer disease, Arch Neurol, vol.65, issue.3, pp.323-328, 2008.

S. A. Small and S. Gandy, Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis, Neuron, vol.52, issue.1, pp.15-31, 2006.

E. M. Snyder, Y. Nong, C. G. Almeida, S. Paul, T. Moran et al., Regulation of NMDA receptor trafficking by amyloidbeta, Nat Neurosci, issue.8, pp.1051-1059, 2005.

S. K. Sonkusare, C. L. Kaul, and P. Ramarao, Dementia of Alzheimer's disease and other neurodegenerative disorders-memantine, a new hope, Pharmacol Res, vol.51, issue.1, pp.1-17, 2005.

R. Spoelgen, C. A. Arnim, A. V. Thomas, I. D. Peltan, M. Koker et al., Interaction of the cytosolic domains of sorLA/LRl 1 with the amyloid precursor protein (APP) and beta-secretase beta-site APP-cleaving enzyme, J Neurosci, vol.26, issue.2, pp.418-428, 2006.

P. H. St-george-hyslop, Molecular genetics of Alzheimer's disease, Biol Psychiatry, vol.47, issue.3, pp.183-199, 2000.

H. Steiner, E. Winkler, D. Edbauer, S. Prokop, G. Basset et al., , 2002.

, PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin, J Biol Chem, vol.277, issue.42, pp.39062-39065

D. Strozyk, K. Blennow, L. R. White, and L. J. Launer, CSF A 42 levels correlate with amyloid-neuropathology in a population-based autopsy study, Neurology, vol.60, issue.4, pp.652-658, 2003.

C. P. Sullivan, A. G. Jay, E. C. Stack, M. Pakaluk, E. Wadlinger et al., , 2011.

, Retromer disruption promotes amyloidogenic APP processing, Neurobiol Pis, vol.43, issue.2, pp.338-345

N. Suzuki, T. T. Cheung, X. D. Cai, A. Odaka, L. Otvos et al., An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants, Science, vol.264, issue.5163, pp.1336-1376, 1994.

M. Takami, Y. Nagashima, Y. Sano, S. Ishihara, M. Morishima-kawashima et al., gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment, J Neurosci, vol.29, issue.41, pp.13042-13052, 2009.

N. Takasugi, T. Tomita, I. Hayashi, M. Tsuruoka, M. Niimura et al., The role of presenilin cofactors in the gamma-secretase complex, Nature, vol.422, issue.6930, pp.438-479, 2003.

K. Takeda, W. Araki, H. Akiyama, and T. Tabira, Amino-truncated amyloid beta-peptide (Abeta5-40/42) produced from caspase-cleaved amyloid precursor protein is deposited in Alzheimer's disease brain, FASEB J, vol.18, issue.14, pp.1755-1777, 2004.

B. L. Tang, Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors, Cell Adh Migr, vol.3, issue.1, pp.118-128, 2009.

T. Tapiola, I. Alafuzoff, and S. Herukka, Cerebrospinal fluid ?-amyloid 42 and tau proteins as biomarkers of alzheimer-type pathologic changes in the brain, Arch Neurol, vol.66, issue.3, pp.382-391, 2009.

C. J. Taylor, D. R. Ireland, I. Ballagh, K. Bourne, N. M. Marechal et al., Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory, Neurobiol Dis, vol.31, issue.2, pp.250-260, 2008.
DOI : 10.1016/j.nbd.2008.04.011

D. R. Thal, I. Sassin, C. Schultz, C. Haass, E. Braak et al., Fleecy amyloid deposits in the internal layers of the human entorhinal cortex are comprised of N-terminal truncated fragments of Abeta, J Neuropathol Exp Neurol, vol.58, issue.2, pp.210-216, 1999.

G. Thinakaran, D. R. Borchelt, M. K. Lee, H. H. Slunt, L. Spitzer et al., Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo, Neuron, vol.17, issue.1, pp.181-190, 1996.

G. Thinakaran and E. H. Koo, Amyloid precursor protein trafficking, processing, and function, J Biol Chem, vol.283, issue.44, pp.29615-29619, 2008.
DOI : 10.1074/jbc.r800019200

URL : http://www.jbc.org/content/283/44/29615.full.pdf

P. J. Tienari, N. Ida, E. Ikonen, M. Simons, A. Weidemann et al., Intracellular and secreted Alzheimer beta-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons, Proc Natl Acad Sci U S A, vol.94, issue.8, pp.4125-4155, 1997.

P. Tremml, H. P. Lipp, U. Müller, L. Ricceri, and D. P. Wolfer, Neurobehavioral development, adult openfield exploration and swimming navigation learning in mice with a modified betaamyloid precursor protein gene, Behav Brain Res, vol.95, issue.1, pp.65-76, 1998.

P. R. Turner, K. O'connor, W. P. Tate, and W. C. Abraham, Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory, Prog Neurobiol, vol.70, issue.1, pp.1-32, 2003.

S. J. Tyler, D. Dawbarn, G. K. Wilcock, and S. J. Allen, alpha-and beta-secretase: profound changes in Alzheimer's disease, Biochem Biophys Res Commun, vol.299, issue.3, pp.373-376, 2002.

B. N. Vardarajan, Y. Zhang, J. H. Lee, R. Cheng, C. Bohm et al., Coding mutations in SORL1 and Alzheimer disease, Ann Neurol, vol.77, issue.2, pp.215-242, 2015.

R. Vassar, B. D. Bennett, S. Babu-khan, S. Kahn, E. A. Mendiaz et al., Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE, Science, vol.286, issue.5440, pp.735-741, 1999.

S. I. Vieira, S. Rebelo, H. Esselmann, J. Wiltfang, J. Lah et al., Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated, Mol Neurodegener, vol.5, p.40, 2010.

V. Vingtdeux, M. Hamdane, A. Loyens, P. Gelé, H. Drobeck et al., Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies, J Biol Chem, vol.282, issue.25, pp.18197-205, 2007.

R. C. Von-rotz, B. M. Kohli, J. Bosset, M. Meier, T. Suzuki et al., The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor, J Cell Sci, vol.117, pp.4435-4448, 2004.

D. M. Walsh, B. P. Tseng, R. E. Rydel, M. B. Podlisny, and D. J. Selkoe, The oligomerization of amyloid beta-protein begins intracellularly in cells derived from human brain, Biochemistry, vol.39, issue.35, pp.10831-10840, 2000.

J. F. Wang, R. Lu, and Y. Z. Wang, Regulation of beta cleavage of amyloid precursor protein, Neurosci Bull, vol.26, issue.5, pp.417-427, 2010.

A. Weidemann, G. König, D. Bunke, P. Fischer, J. M. Salbaum et al., , 1989.

, Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein, Cell, vol.57, issue.1, pp.115-126

A. Weidemann, S. Eggert, F. B. Reinhard, M. Vogel, K. Paliga et al., A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing, Biochemistry, vol.41, issue.8, pp.2825-2835, 2002.

A. M. Wertkin, R. S. Turner, S. J. Pleasure, T. E. Golde, S. G. Younkin et al., , 1993.

, Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides, Proc Natl Acad Sci U S A, vol.90, issue.20, pp.9513-9520

U. B. Westergaard, E. S. Sorensen, G. Hermey, M. S. Nielsen, A. Nykjaer et al., Functional organization of the sortilin Vps10p domain, J Biol Chem, vol.279, issue.48, pp.50221-50230, 2004.