H. C. Blair, C. Quitterie, Y. Larrouture, H. Li, D. Lin et al., 2017. « Osteoblast Differentiation and Bone Matrix Formation In Vivo and In Vitro, Tissue Engineering Part B: Reviews, vol.23, issue.3, pp.268-80
URL : https://hal.archives-ouvertes.fr/hal-02191238

L. F. Bonewald, The Amazing Osteocyte, vol.26, pp.229-267, 2011.

M. J. Bosse, H. E. Gruber, and K. Warren, Ramp. s. d. « Internalization of Bacteria by Osteoblasts in a Patient with Recurrent, Long-Term Osteomyelitis, p.5

B. F. Boyce, L. Et, and . Xing, « Functions of RANKL/RANK/OPG in Bone Modeling and Remodeling, Archives of Biochemistry and Biophysics, vol.473, issue.2, pp.139-185, 2008.

B. F. Boyce, Z. Yao, L. Et, and . Xing, « Osteoclasts Have Multiple Roles in Bone in Addition to Bone Resorption, Critical Reviews in Eukaryotic Gene Expression, vol.19, issue.3, pp.171-80, 2009.

P. M. Brown, D. James, J. C. Hutchison, and . Crockett, « Absence of Glutamine Supplementation Prevents Differentiation of Murine Calvarial Osteoblasts to a Mineralizing Phenotype, Calcified Tissue International, vol.89, issue.6, pp.472-82, 2011.

J. E. Cassat, D. Neal, J. P. Hammer, M. A. Campbell, D. S. Benson et al., « A Secreted Bacterial Protease Tailors the Staphylococcus Aureus Virulence Repertoire to Modulate Bone Remodeling during Osteomyelitis, Cell Host & Microbe, vol.13, issue.6, pp.759-72, 2013.


C. H. Chung, E. E. Golub, E. Forbes, T. Tokuoka, and I. M. Shapiro, « Mechanism of Action of Beta-Glycerophosphate on Bone Cell Mineralization, Calcified Tissue International, vol.51, issue.4, pp.305-316, 1992.

I. Couret, S. Dharmawardhane, D. Brownson, M. Lennartz, and G. M. Bokoch, « Localization of P21-Activated Kinase 1 (PAK1) to Pseudopodia, Membrane Ruffles, and Phagocytic Cups in Activated Human Neutrophils, Biologie du remodelage osseux ». Médecine Nucléaire, 9, vol.66, pp.521-548, 1999.

J. K. Ellington, S. S. Reilly, W. K. Ramp, M. S. Smeltzer, J. F. Kellam et al., « Mechanisms OfStaphylococcus Aureusinvasion of Cultured Osteoblasts, Microbial Pathogenesis, vol.26, issue.6, pp.317-340, 1999.

J. K. Ellington, M. Harris, L. Webb, B. Smith, T. Smith et al., Intracellular Staphylococcus Aureus: A MECHANISM FOR THE INDOLENCE OF OSTEOMYELITIS, vol.85, pp.918-939, 2003.

. Feng, J. M. Xu, and . Mcdonald, Disorders of Bone Remodeling, vol.6, pp.121-166, 2011.

B. Fournier and D. J. Philpott, « Recognition of Staphylococcus Aureus by the Innate Immune System, Clinical Microbiology Reviews, vol.18, issue.3, pp.521-561, 2005.

T. Fowler, S. Johansson, K. K. Wary, and M. Hook, « Src Kinase Has a Central Role in in Vitro Cellular Internalization of Staphylococcus Aureus », Cellular Microbiology, vol.5, issue.6, pp.417-443, 2003.

R. Fujisawa, Acidic Bone Matrix Proteins and Their Roles in Calcification, Frontiers in Bioscience, vol.17, issue.1, p.1891, 2012.

D. J. Hadjidakis and I. I. Androulakis, Bone Remodeling, vol.1092, pp.385-96, 2006.


S. Hadzir, . Norhaiza, R. Siti-norsaidah-ibrahim, and . Wahab, Zaidah Zainal Ariffin, Mohamad Abdul Razak, et Shahrul Hisham Zainal Ariffin, Ascorbic Acid Induces Osteoblast Differentiation of Human Suspension Mononuclear Cells, vol.16, pp.674-82, 2014.

Z. Hamidouche, O. Fromigué, J. Ringe, T. Häupl, P. Vaudin et al., « Priming Integrin Alpha5 Promotes Human Mesenchymal Stromal Cell Osteoblast Differentiation and Osteogenesis, Proceedings of the National Academy of Sciences of the United States of America, vol.106, pp.18587-91, 2009.

S. Herbert, A. K. Ziebandt, K. Ohlsen, T. Schafer, M. Hecker et al., « Repair of Global Regulators in Staphylococcus Aureus 8325 and Comparative Analysis with Other Clinical Isolates, Infection and Immunity, vol.78, issue.6, pp.2877-89, 2010.

C. Hoffmann, A. Berking, F. Agerer, A. Buntru, F. Neske et al., « Caveolin Limits Membrane Microdomain Mobility and Integrin-Mediated Uptake of Fibronectin-Binding Pathogens », Journal of Cell Science, vol.123, issue.24, pp.4280-91, 2010.

F. J. Hughes and W. Turner, Georgios Belibasakis, et Gianluca Martuscelli. 2006. « Effects of Growth Factors and Cytokines on Osteoblast Differentiation, vol.41, pp.48-72, 2000.

B. D. Jett, M. S. Et, and . Gilmore, « Internalization of Staphylococcus Aureus by Human Corneal Epithelial Cells: Role of Bacterial Fibronectin-Binding Protein and Host Cell Factors, Infection and Immunity, vol.70, issue.8, pp.4697-4700, 2002.

J. Josse, F. Velard, S. C. Et, and . Gangloff, Staphylococcus Aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis, vol.5, 2015.
URL : https://hal.archives-ouvertes.fr/hal-02163998


J. Josse, F. Laurent, and A. Diot, « Staphylococcal Adhesion and Host Cell Invasion: Fibronectin-Binding and Other Mechanisms ». Frontiers in Microbiology, vol.8, 2017.

K. B. Kaplan, J. R. Swedlow, D. O. Morgan, and H. E. Varmus, C-Src Enhances the Spreading of Src-/-Fibroblasts on Fibronectin by a Kinase-Independent Mechanism, vol.9, pp.1505-1522, 1995.

N. Kavanagh, J. Fergal, S. W. O'brien, and . Kerrigan, « Staphylococcus Aureus Protein A Causes Osteoblasts to Hyper-Mineralise in a 3D ExtraCellular Matrix Environment, PloS One, vol.13, issue.6, 2018.

. Kintarak, S. A. Sompid, P. M. Whawell, S. Speight, S. P. Packer et al., Internalization of Staphylococcus Aureus by Human Keratinocytes, vol.72, pp.5668-75, 2004.


C. B. Landersdorfer, « Penetration of Antibacterials into Bone, Clin Pharmacokinet, p.36, 2009.

E. Laurent, G. Gras, J. Druon, P. Rosset, S. Baron et al., « Key Features of Bone and Joint Infections Following the Implementation of Reference Centers in France, Medecine Et Maladies Infectieuses, vol.48, issue.4, pp.256-62, 2018.


P. Liu, M. Rudick, G. W. Et-richard, and . Anderson, « Multiple Functions of Caveolin-1 », Journal of Biological Chemistry, vol.277, issue.44, pp.41295-98, 2002.

Y. H. Liu, D. Huang, Z. J. Li, X. H. Li, X. Wang et al., Toll-like Receptor-4-Dependence of the Lipopolysaccharide-Mediated Inhibition of Osteoblast Differentiation, vol.15, 2016.

S. C. Murphy, S. Fernandez-pol, P. H. Chung, S. N. Prasanna-murthy, S. B. Milne et al., Narla Mohandas, et Kasturi Haldar, Cytoplasmic Remodeling of Erythrocyte Raft Lipids during Infection by the Human Malaria Parasite Plasmodium Falciparum, vol.110, pp.2132-2171, 2007.

A. Navarro, B. Anand-apte, and M. Parat, « A Role for Caveolae in Cell Migration, FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology, vol.18, issue.15, pp.1801-1812, 2004.

A. Ogston, « Report upon Micro-Organisms in Surgical Diseases, British Medical Journal, vol.1, pp.369-371, 1054.

M. E. Olson, A. R. Et, and . Horswill, « Staphylococcus Aureus Osteomyelitis: Bad to the Bone, Cell Host & Microbe, vol.13, issue.6, pp.629-660, 2013.

A. M. Powelka, J. Sun, J. Li, M. Gao, L. M. Shaw et al., Stimulation-Dependent Recycling of Integrin ?1 Regulated by ARF6 and Rab11: Integrin Recycling Regulated by ARF6 and Rab11, vol.5, pp.20-36, 2004.

L. S. Price, J. Leng, M. A. Schwartz, and G. M. Bokoch, Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading, vol.9, pp.1863-71, 1998.


J. Rasigade, S. Trouillet-assant, T. Ferry, A. Binh, A. Diep et al., PSMs of Hypervirulent Staphylococcus Aureus Act as Intracellular Toxins That Kill Infected Osteoblasts, vol.8, p.63176, 2013.
URL : https://hal.archives-ouvertes.fr/hal-01917856

A. Reich, A. S. Bae, A. M. Barnes, W. A. Cabral, A. Hinek et al., « Type V OI Primary Osteoblasts Display Increased Mineralization despite Decreased COL1A1 Expression, The Journal of Clinical Endocrinology and Metabolism, vol.100, issue.2, 2015.

C. J. Sanchez, C. L. Ward, D. R. Romano, J. Brady, . Hurtgen et al., « Staphylococcus Aureus Biofilms Decrease Osteoblast Viability, Inhibits Osteogenic Differentiation, and Increases Bone Resorption in Vitro, BMC Musculoskeletal Disorders, vol.14, issue.1, 2013.


N. Sawada, Y. Taketani, N. Amizuka, M. Ichikawa, C. Ogawa et al., « Caveolin-1 in Extracellular Matrix Vesicles Secreted from Osteoblasts, Bone, vol.41, issue.1, pp.52-58, 2007.

F. Shi, J. Et, and . Sottile, « Caveolin-1-Dependent 1 Integrin Endocytosis Is a Critical Regulator of Fibronectin Turnover », Journal of Cell Science, vol.121, issue.14, pp.2360-71, 2008.

S. Shi, X. Et, and . Zhang, Interaction of Staphylococcus Aureus with Osteoblasts, vol.3, pp.367-70, 2012.

W. S. Simonet, D. Lacey, C. Dunstan, M. Kelley, . Chang et al., « Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density, Cell, vol.89, issue.2, pp.309-328, 1997.

, , pp.80209-80212

K. R. Solomon, D. Layla, D. A. Adolphson, K. P. Wank, . Mchugh et al., Caveolae in Human and Murine Osteoblasts, vol.15, pp.2391-2401, 2000.


J. M. Sung, D. H. Lloyd, and J. A. Lindsay, « Staphylococcus Aureus Host Specificity: Comparative Genomics of Human versus Animal Isolates by MultiStrain Microarray, Microbiology, vol.154, issue.7, pp.1949-59, 2008.


A. J. Tande, R. Et, and . Patel, Prosthetic Joint Infection, vol.27, pp.302-347, 2014.
URL : https://hal.archives-ouvertes.fr/hal-01130448

S. M. Thomas and J. S. Brugge, « Cellular Functions Regulated by Src Family Kinases, Annual Review of Cell and Developmental Biology, vol.13, pp.513-609, 1997.

S. Trouillet-assant, M. Gallet, P. Nauroy, J. Rasigade, S. Flammier et al., Leading to Increased Bone Resorption, Dual Impact of Live Staphylococcus Aureus on the Osteoclast Lineage, vol.211, pp.571-81, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01953681

S. Trouillet-assant, L. Lelièvre, P. Martins-simões, L. Gonzaga, J. Tasse et al., « Adaptive Processes of Staphylococcus Aureus Isolates during the Progression from Acute to Chronic Bone and Joint Infections in Patients: S. Aureus Adaptation during BJI », Cellular Microbiology, vol.18, issue.10, pp.1405-1419, 2016.


M. Vernejoul and . Marie, Cellules osseuses et remodelage osseux. » médecine/sciences, vol.9, p.1192, 1993.

F. A. Waldvogel, G. Medoff, and M. N. Swartz, Osteomyelitis: A Review of Clinical Features, Therapeutic Considerations and Unusual Aspects, vol.282, pp.198-206, 1970.