L. Membrane, 2A: peptide (21 aa) auto-clivable pour production équimolaire des gènes en amont et en aval, pp.89-90

A. A. Ajibade, H. Y. Wang, W. , and R. , Cell type-specific function of TAK1 in innate immune signaling, Trends in Immunology, vol.34, issue.7, pp.307-316, 2013.
DOI : 10.1016/j.it.2013.03.007

V. Annibali, G. Ristori, D. F. Angelini, B. Serafini, R. Mechelli et al., CD161highCD8+T cells bear pathogenetic potential in multiple sclerosis, Brain, vol.134, issue.2, pp.542-554, 2011.
DOI : 10.1093/brain/awq354

B. Arden, S. P. Clark, D. Kabelitz, and T. W. Mak, Human T-cell receptor variable gene segment families, Immunogenetics, vol.42, issue.6, pp.455-500, 1995.
DOI : 10.1007/BF00172176

H. Babbe, A. Roers, A. Waisman, H. Lassmann, N. Goebels et al., T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction, The Journal of Experimental Medicine, vol.150, issue.3, pp.393-404, 2000.
DOI : 10.1016/0198-8859(96)00084-5

H. Babbe, A. Roers, A. Waisman, H. Lassmann, N. Goebels et al., T Cells Dominate the T Cell Infiltrate in Active Multiple Sclerosis Lesions as Shown by Micromanipulation and Single Cell Polymerase Chain Reaction, The Journal of Experimental Medicine, vol.150, issue.3, pp.393-404, 2000.
DOI : 10.1016/0198-8859(96)00084-5

B. Becher, S. Spath, and J. Goverman, Cytokine networks in neuroinflammation, Nature Reviews Immunology, vol.72, issue.1, pp.49-59, 2017.
DOI : 10.1097/NEN.0b013e3182909f2f

L. Berthelot, D. Laplaud, S. Pettré, C. Ballet, L. Michel et al., T cell responses against myelin determinants in multiple sclerosis and healthy individuals, European Journal of Immunology, vol.34, issue.7, pp.1889-1899, 2008.
DOI : 10.4049/jimmunol.175.12.8365

A. Bitsch, J. Schuchardt, S. Bunkowski, T. Kuhlmann, and W. Brück, Acute axonal injury in multiple sclerosis: Correlation with demyelination and inflammation, Brain, vol.123, issue.6, pp.1174-1183, 2000.
DOI : 10.1093/brain/123.6.1174

J. Booss, M. M. Esiri, W. W. Tourtellotte, and D. Y. Mason, Immunohistological analysis of T lymphocyte subsets in the central nervous system in chronic progressive multiple sclerosis, Journal of the Neurological Sciences, vol.62, issue.1-3, pp.219-232, 1983.
DOI : 10.1016/0022-510X(83)90201-0

A. Boucher, M. Desforges, P. Duquette, T. , and P. J. , Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients, Clinical Immunology, vol.123, issue.3, pp.258-267, 2007.
DOI : 10.1016/j.clim.2007.02.002

A. Brickshawana, S. R. Hinson, M. F. Romero, C. F. Lucchinetti, Y. Guo et al., Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: a comparative study, The Lancet Neurology, vol.13, issue.8, pp.795-806, 2014.
DOI : 10.1016/S1474-4422(14)70141-3

A. Compston and A. Coles, Multiple sclerosis, The Lancet, vol.372, issue.9648, pp.1502-1517, 2008.
DOI : 10.1016/S0140-6736(08)61620-7

URL : https://hal.archives-ouvertes.fr/hal-00996686

C. Confavreux, S. Vukusic, T. Moreau, and P. Adeleine, Relapses and Progression of Disability in Multiple Sclerosis, New England Journal of Medicine, vol.343, issue.20, pp.1430-1438, 2000.
DOI : 10.1056/NEJM200011163432001

A. Corthay, K. S. Nandakumar, and R. Holmdahl, Evaluation of the Percentage of Peripheral T Cells with Two Different T Cell Receptor ??-Chains and of their Potential Role in Autoimmunity, Journal of Autoimmunity, vol.16, issue.4, pp.423-429, 2001.
DOI : 10.1006/jaut.2001.0504

M. P. Crawford, S. X. Yan, S. B. Ortega, R. S. Mehta, R. E. Hewitt et al., High prevalence of autoreactive, neuroantigen-specific CD8+ T cells in multiple sclerosis revealed by novel flow cytometric assay, Blood, vol.103, issue.11, pp.4222-4231, 2004.
DOI : 10.1182/blood-2003-11-4025

M. M. Davis and P. J. Bjorkman, T-cell antigen receptor genes and T-cell recognition, Nature, vol.334, issue.6181, pp.395-402, 1988.
DOI : 10.1038/334395a0

D. Jager, P. L. Baecher-allan, C. Maier, L. M. Arthur, A. T. Ottoboni et al., The role of the CD58 locus in multiple sclerosis, Proceedings of the National Academy of Sciences, vol.33, issue.2, pp.5264-5269, 2009.
DOI : 10.1038/ng1071

N. Degauque, S. Brouard, and J. Soulillou, Cross-Reactivity of TCR Repertoire: Current Concepts, Challenges, and Implication for Allotransplantation, Frontiers in Immunology, vol.65, p.89, 2016.
DOI : 10.1097/00007890-199804150-00008

L. Durelli, L. Conti, M. Clerico, D. Boselli, G. Contessa et al., T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-??, Annals of Neurology, vol.33, issue.5, pp.499-509, 2009.
DOI : 10.1212/WNL.33.11.1444

M. F. Farez, M. P. Fiol, M. I. Gaitán, F. J. Quintana, C. et al., Sodium intake is associated with increased disease activity in multiple sclerosis, Journal of Neurology, Neurosurgery & Psychiatry, vol.11, issue.(3), pp.26-31, 2015.
DOI : 10.1016/S1474-4422(12)70241-7

D. Franceschini, D. Porto, P. Piconese, S. Trella, E. Accapezzato et al., Polyfunctional Type-1, -2, and -17 CD8+ T Cell Responses to Apoptotic Self-Antigens Correlate with the Chronic Evolution of Hepatitis C Virus Infection, PLoS Pathogens, vol.345, issue.6, 2012.
DOI : 10.1371/journal.ppat.1002759.s011

URL : https://hal.archives-ouvertes.fr/pasteur-00966408

A. Fromont, C. Binquet, E. A. Sauleau, I. Fournel, A. Bellisario et al., Geographic variations of multiple sclerosis in France, Brain, vol.133, issue.7, 2010.
DOI : 10.1093/brain/awq134

T. Goldmann, P. Wieghofer, P. F. Müller, Y. Wolf, D. Varol et al., A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation, Nature Neuroscience, vol.12, issue.11, pp.1618-1626, 2013.
DOI : 10.1186/1471-2091-12-34

P. Gourraud, H. F. Harbo, S. L. Hauser, and S. E. Baranzini, The genetics of multiple sclerosis: an up-to-date review, Immunological Reviews, vol.61, issue.Suppl., pp.87-103, 2012.
DOI : 10.1016/S0002-9297(07)64074-9

J. Goverman, Autoimmune T cell responses in the central nervous system, Nature Reviews Immunology, vol.30, issue.6, pp.393-407, 2009.
DOI : 10.4049/jimmunol.178.10.6092

B. Gran, D. Gestri, A. Sottini, E. Quiròs-roldàn, A. Bettinardi et al., Detection of skewed T-cell receptor V-?? gene usage in the peripheral blood of patients with multiple sclerosis, Journal of Neuroimmunology, vol.85, issue.1, pp.22-32, 1998.
DOI : 10.1016/S0165-5728(97)00250-6

D. R. Green, N. Droin, and M. Pinkoski, Activation-induced cell death in T cells, Immunological Reviews, vol.166, issue.1, pp.70-81, 2003.
DOI : 10.4049/jimmunol.166.2.1028

C. T. Harp, A. E. Lovett-racke, M. K. Racke, E. M. Frohman, and N. L. Monson, Impact of myelin-specific antigen presenting B cells on T cell activation in multiple sclerosis, Clinical Immunology, vol.128, issue.3, pp.382-391, 2008.
DOI : 10.1016/j.clim.2008.05.002

S. L. Hauser, A. K. Bhan, F. Gilles, M. Kemp, C. Kerr et al., Immunohistochemical analysis of the cellular infiltrate in multiple sclerosis lesions, Annals of Neurology, vol.248, issue.6, pp.578-587, 1986.
DOI : 10.1212/WNL.29.11.1504

S. L. Hauser, E. Waubant, D. L. Arnold, T. Vollmer, J. Antel et al., B-Cell Depletion with Rituximab in Relapsing???Remitting Multiple Sclerosis, New England Journal of Medicine, vol.358, issue.7, pp.676-688, 2008.
DOI : 10.1056/NEJMoa0706383

E. Havrdová, A. Belova, A. Goloborodko, A. Tisserant, A. Wright et al., Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study, Journal of Neurology, vol.4, issue.7, 2016.
DOI : 10.1371/journal.pone.0004725

A. K. Hedström, T. Olsson, and L. And-alfredsson, Smoking is a major preventable risk factor for multiple sclerosis, Multiple Sclerosis Journal, vol.16, issue.8, 2015.
DOI : 10.1159/000368553

R. Höftberger, F. Aboul-enein, W. Brueck, C. Lucchinetti, M. Rodriguez et al., Expression of Major Histocompatibility Complex class l Molecules on the Different Cell Types in Multiple Sclerosis Lesions, Brain Pathology, vol.74, issue.1, pp.43-50, 2004.
DOI : 10.1016/0022-510X(86)90100-0

E. Hooijberg, A. Q. Bakker, J. J. Ruizendaal, and H. Spits, NFAT-controlled expression of GFP permits visualization and isolation of antigen-stimulated primary human T cells, Blood, vol.96, pp.459-466, 2000.

I. Ifergan, H. Kebir, J. I. Alvarez, G. Marceau, M. Bernard et al., Central nervous system recruitment of effector memory CD8+ T lymphocytes during neuroinflammation is dependent on ??4 integrin, Brain, vol.134, issue.12, pp.3560-3577, 2011.
DOI : 10.1093/brain/awr268

URL : https://hal.archives-ouvertes.fr/pasteur-00723279

D. A. Hafler, A. Compston, S. Sawcer, E. S. Lander, M. J. Daly et al., Risk alleles for multiple sclerosis identified by a genomewide study, N. Engl. J. Med, vol.357, pp.851-862, 2007.

M. Jacobsen, S. Cepok, E. Quak, M. Happel, R. Gaber et al., Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients, Brain, vol.125, issue.3, pp.538-550, 2002.
DOI : 10.1093/brain/awf059

A. Junker, J. Ivanidze, J. Malotka, I. Eiglmeier, H. Lassmann et al., Multiple sclerosis: T-cell receptor expression in distinct brain regions, Brain, vol.130, issue.11, pp.2789-2799, 2007.
DOI : 10.1093/brain/awm214

A. Jurewicz, W. E. Biddison, and J. P. Antel, MHC class I-restricted lysis of human oligodendrocytes by myelin basic protein peptide-specific CD8 T lymphocytes, J. Immunol. Baltim. Md, vol.160, pp.3056-3059, 1950.

L. Kappos, E. Radue, P. O-'connor, C. Polman, R. Hohlfeld et al., A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis, New England Journal of Medicine, vol.362, issue.5, pp.387-401, 2010.
DOI : 10.1056/NEJMoa0909494

URL : https://hal.archives-ouvertes.fr/hal-00617764

J. Karttunen, S. Sanderson, and N. Shastri, Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens., Proc. Natl, 1992.
DOI : 10.1073/pnas.89.13.6020

E. Kekäläinen, A. Hänninen, M. Maksimow, and T. P. Arstila, T cells expressing two different T cell receptors form a heterogeneous population containing autoreactive clones, Molecular Immunology, vol.48, issue.1-3, pp.211-218, 2010.
DOI : 10.1016/j.molimm.2010.08.008

L. Klein, M. Klugmann, K. A. Nave, V. K. Tuohy, and B. Kyewski, Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells, Nature Medicine, vol.159, issue.1, pp.56-61, 2000.
DOI : 10.1084/jem.163.2.231

J. F. Kurtzke, A REASSESSMENT OF THE DISTRIBUTION OF MULTIPLE SCLEROSIS, Acta Neurologica Scandinavica, vol.50, issue.Suppl. 19, pp.137-157, 1975.
DOI : 10.1111/j.1600-0404.1974.tb01347.x

D. Laplaud, C. , and C. , [Etiology of multiple sclerosis], Rev. Prat, vol.56, pp.1306-1312, 2006.

D. Laplaud, C. Ruiz, S. Wiertlewski, S. Brouard, L. Berthelot et al., Blood T-cell receptor ?? chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution, Brain, vol.127, issue.5, pp.981-995, 2004.
DOI : 10.1093/brain/awh119

D. Laplaud, L. Berthelot, P. Miqueu, K. Bourcier, J. Moynard et al., Serial blood T cell repertoire alterations in multiple sclerosis patients; correlation with clinical and MRI parameters, Journal of Neuroimmunology, vol.177, issue.1-2, pp.151-160, 2006.
DOI : 10.1016/j.jneuroim.2006.05.006

C. Larochelle, M. Lécuyer, J. I. Alvarez, M. Charabati, O. Saint-laurent et al., Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation, Annals of Neurology, vol.108, issue.pt 12, pp.39-53, 2015.
DOI : 10.1073/pnas.1017854108

H. Lassmann, Experimental models of multiple sclerosis, Revue Neurologique, vol.163, issue.6-7, pp.651-655, 2007.
DOI : 10.1016/S0035-3787(07)90474-9

M. Lefranc, V. Giudicelli, C. Ginestoux, J. Jabado-michaloud, G. Folch et al., IMGT(R), the international ImMunoGeneTics information system(R), Nucleic Acids Research, vol.37, issue.Database, pp.1006-1012, 2009.
DOI : 10.1093/nar/gkn838

URL : https://hal.archives-ouvertes.fr/hal-00357158

E. Leray, T. Moreau, A. Fromont, and G. Edan, Epidemiology of multiple sclerosis, Revue Neurologique, vol.172, issue.1, pp.3-13, 2016.
DOI : 10.1016/j.neurol.2015.10.006

URL : https://hal.archives-ouvertes.fr/hal-01255824

J. E. Libbey, M. F. Cusick, and R. S. Fujinami, Role of Pathogens in Multiple Sclerosis, International Reviews of Immunology, vol.46, issue.1, pp.266-283, 2014.
DOI : 10.1016/j.jcv.2009.05.019

J. W. Lindsey and L. M. Hatfield, Epstein-Barr virus and multiple sclerosis: Cellular immune response and cross-reactivity, Journal of Neuroimmunology, vol.229, issue.1-2, pp.238-242, 2010.
DOI : 10.1016/j.jneuroim.2010.08.009

F. Lolli, H. Martini, A. Citro, D. Franceschini, E. Portaccio et al., Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis, Journal of Neuroinflammation, vol.35, issue.1, p.94, 2013.
DOI : 10.1016/j.immuni.2011.07.010

A. Louveau, I. Smirnov, T. J. Keyes, J. D. Eccles, S. J. Rouhani et al., Structural and functional features of central nervous system lymphatic vessels, Nature, vol.14, issue.7560, pp.337-341, 2015.
DOI : 10.1097/00019052-200106000-00006

A. E. Lovett-racke, Y. Yang, R. , and M. K. , Th1 versus Th17: Are T cell cytokines relevant in multiple sclerosis?, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1812, issue.2, pp.246-251, 2011.
DOI : 10.1016/j.bbadis.2010.05.012

URL : https://hal.archives-ouvertes.fr/hal-00652650

P. Lozeron, D. Chabas, B. Duprey, O. Lyon-caen, and R. Liblau, T cell receptor V beta 5 and V beta 17 clonal diversity in cerebrospinal fluid and peripheral blood lymphocytes of multiple sclerosis patients, Mult. Scler. Houndmills Basingstoke Engl, vol.4, pp.154-161, 1998.

C. Malmeström, J. Lycke, S. Haghighi, O. Andersen, L. Carlsson et al., Relapses in multiple sclerosis are associated with increased CD8+ T-cell mediated cytotoxicity in CSF, Journal of Neuroimmunology, vol.196, issue.1-2, pp.159-165, 2008.
DOI : 10.1016/j.jneuroim.2008.03.001

M. Boneschi, F. Vacchi, L. Rovaris, M. Capra, R. et al., Mitoxantrone for multiple sclerosis, Cochrane Database Syst. Rev, p.2127, 2013.

I. Medana, M. A. Martinic, H. Wekerle, and H. Neumann, Transection of Major Histocompatibility Complex Class I-Induced Neurites by Cytotoxic T Lymphocytes, The American Journal of Pathology, vol.159, issue.3, pp.809-815, 2001.
DOI : 10.1016/S0002-9440(10)61755-5

M. Mehling, R. Lindberg, F. Raulf, J. Kuhle, C. Hess et al., Th17 central memory T cells are reduced by FTY720 in patients with multiple sclerosis, Neurology, vol.75, issue.5, pp.403-410, 2010.
DOI : 10.1212/WNL.0b013e3181ebdd64

U. Meier, G. Giovannoni, J. S. Tzartos, and G. Khan, Translational Mini-Review Series on B cell subsets in disease. B cells in multiple sclerosis: drivers of disease pathogenesis and Trojan horse for Epstein-Barr virus entry to the central nervous system?, Clinical & Experimental Immunology, vol.68, issue.1, pp.1-6, 2012.
DOI : 10.1002/ana.22081

M. O. Melcon, J. Correale, and C. M. Melcon, Is it time for a new global classification of multiple sclerosis?, Journal of the Neurological Sciences, vol.344, issue.1-2, pp.171-181, 2014.
DOI : 10.1016/j.jns.2014.06.051

D. H. Miller, O. A. Khan, W. A. Sheremata, L. D. Blumhardt, G. P. Rice et al., A Controlled Trial of Natalizumab for Relapsing Multiple Sclerosis, New England Journal of Medicine, vol.348, issue.1, pp.15-23, 2003.
DOI : 10.1056/NEJMoa020696

Y. Miyazaki, S. Miyake, A. Chiba, O. Lantz, Y. et al., Mucosal-associated invariant T cells regulate Th1 response in multiple sclerosis, International Immunology, vol.23, issue.9, pp.529-535, 2011.
DOI : 10.1093/intimm/dxr047

N. Molnarfi, U. Schulze-topphoff, M. S. Weber, J. C. Patarroyo, T. Prod-'homme et al., MHC class II???dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies, The Journal of Experimental Medicine, vol.139, issue.13, 2013.
DOI : 10.1016/0165-5728(92)90213-5

J. Monteiro, R. Hingorani, R. Peroglizzi, B. Apatoff, and P. K. Gregersen, Oligoclonality of CD8 + T cells in Multiple Sclerosis, Autoimmunity, vol.152, issue.2, pp.127-138, 1996.
DOI : 10.1016/S1074-7613(95)80079-4

M. Montes, X. Zhang, L. Berthelot, D. Laplaud, S. Brouard et al., Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells, Clinical Immunology, vol.130, issue.2, pp.133-144, 2009.
DOI : 10.1016/j.clim.2008.08.030

M. R. Mulvey, M. Doupe, M. Prout, C. Leong, R. Hizon et al., harbouring Enterotoxin A as a possible risk factor for multiple sclerosis exacerbations, Multiple Sclerosis Journal, vol.13, issue.4, pp.397-403, 2011.
DOI : 10.1177/1352458506070319

K. L. Munger, J. Bentzen, B. Laursen, E. Stenager, N. Koch-henriksen et al., Childhood body mass index and multiple sclerosis risk: a long-term cohort study, Multiple Sclerosis Journal, vol.72, issue.10, 2013.
DOI : 10.1038/oby.2007.603

P. A. Muraro, L. Bonanni, B. Mazzanti, A. Pantalone, E. Traggiai et al., Short-term dynamics of circulating T cell receptor V beta repertoire in relapsing???remitting MS, Journal of Neuroimmunology, vol.127, issue.1-2, pp.149-159, 2002.
DOI : 10.1016/S0165-5728(02)00105-4

E. Nerrant, C. Salsac, M. Charif, X. Ayrignac, C. Carra-dalliere et al., Lack of confirmation of anti-inward rectifying potassium channel 4.1 antibodies as reliable markers of multiple sclerosis, Multiple Sclerosis Journal, vol.21, issue.15, pp.1699-1703, 2014.
DOI : 10.1002/glia.20574

. Nicol, B (2016) p4. Implication des lymphocytes TCD8+ exprimant l'antigène CD161 dans la physiopathologie de la sclérose en plaques

J. Nikolich-zugich, M. K. Slifka, and I. Messaoudi, The many important facets of T-cell repertoire diversity, Nature Reviews Immunology, vol.14, issue.2, pp.123-132, 2004.
DOI : 10.1126/science.286.5446.1913

A. Nylander and D. A. Hafler, Multiple sclerosis, Journal of Clinical Investigation, vol.122, issue.4, pp.1180-1188, 2012.
DOI : 10.1172/JCI58649

J. R. Oksenberg and S. E. Baranzini, Multiple sclerosis genetics???is the glass half full, or half empty?, Nature Reviews Neurology, vol.18, issue.8, pp.429-437, 2010.
DOI : 10.4049/jimmunol.181.8.5473

H. S. Panitch, R. L. Hirsch, A. S. Haley, J. , and K. P. , EXACERBATIONS OF MULTIPLE SCLEROSIS IN PATIENTS TREATED WITH GAMMA INTERFERON, The Lancet, vol.329, issue.8538, pp.893-895, 1987.
DOI : 10.1016/S0140-6736(87)92863-7

C. Phetsouphanh, J. J. Zaunders, and A. D. Kelleher, Detecting Antigen-Specific T Cell Responses: From Bulk Populations to Single Cells, International Journal of Molecular Sciences, vol.8, issue.8, pp.18878-18893, 2015.
DOI : 10.1038/nbt.2938

C. Pierrot-deseilligny and J. Souberbielle, Is hypovitaminosis D one of the environmental risk factors for multiple sclerosis?, Brain, vol.133, issue.7, pp.1869-1888, 2010.
DOI : 10.1093/brain/awq147

E. R. Pierson, I. M. Stromnes, and J. M. Goverman, B Cells Promote Induction of Experimental Autoimmune Encephalomyelitis by Facilitating Reactivation of T Cells in the Central Nervous System, The Journal of Immunology, vol.192, issue.3, pp.929-939, 2014.
DOI : 10.4049/jimmunol.1302171

C. H. Polman, S. C. Reingold, G. Edan, M. Filippi, H. Hartung et al., Diagnostic criteria for multiple sclerosis: 2005 revisions to the ???McDonald Criteria???, Annals of Neurology, vol.6, issue.6, pp.840-846, 2005.
DOI : 10.1212/WNL.53.6.1184

C. H. Polman, S. C. Reingold, B. Banwell, M. Clanet, J. A. Cohen et al., Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria, Annals of Neurology, vol.64, issue.suppl 2, pp.292-302, 2011.
DOI : 10.1002/ana.21464

I. Puisieux, J. Even, C. Pannetier, F. Jotereau, M. Favrot et al., Oligoclonality of tumor-infiltrating lymphocytes from human melanomas, J. Immunol. Baltim. Md, vol.153, pp.2807-2818, 1950.

A. Rao, C. Luo, and P. G. Hogan, TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function, Annual Review of Immunology, vol.15, issue.1, pp.707-747, 1997.
DOI : 10.1146/annurev.immunol.15.1.707

P. M. Rawson, C. Molette, M. Videtta, L. Altieri, D. Franceschini et al., Cross-presentation of caspase-cleaved apoptotic self antigens in HIV infection, Nature Medicine, vol.162, issue.12, pp.1431-1439, 2007.
DOI : 10.1002/eji.200324539

T. M. Rivers, D. H. Sprunt, and G. P. Berry, OBSERVATIONS ON ATTEMPTS TO PRODUCE ACUTE DISSEMINATED ENCEPHALOMYELITIS IN MONKEYS, Journal of Experimental Medicine, vol.58, issue.1, pp.39-53, 1933.
DOI : 10.1084/jem.58.1.39

M. Salou, E. Ngono, A. Garcia, A. Michel, L. Laplaud et al., [Adaptative immunity and pathophysiology of multiple sclerosis, Médecine Interne Fondée Par Société Natl. Francaise Médecine Interne, pp.479-486, 2013.

M. Salou, 2014) p19. Implication des lymphocytes T CD8 + à répertoire restreint dans la sclérose en plaques, Thèse de Doctorat universitaire de Nantes

M. Salou, A. Garcia, L. Michel, A. Gainche-salmon, D. Loussouarn et al., Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis, Annals of Clinical and Translational Neurology, vol.18, issue.Pt 12, pp.609-622, 2015.
DOI : 10.1038/nm.2720

URL : https://hal.archives-ouvertes.fr/hal-01200787

M. Salou, B. Nicol, A. Garcia, D. Baron, L. Michel et al., Neuropathologic, phenotypic and functional analyses of Mucosal Associated Invariant T cells in Multiple Sclerosis, Clinical Immunology, vol.166, issue.167, 2016.
DOI : 10.1016/j.clim.2016.03.014

B. M. Sauer, W. F. Schmalstieg, and C. L. Howe, Axons are injured by antigen-specific CD8+ T cells through a MHC class I- and granzyme B-dependent mechanism, Neurobiology of Disease, vol.59, pp.194-205, 2013.
DOI : 10.1016/j.nbd.2013.07.010

S. Sawcer, R. J. Franklin, and M. Ban, Multiple sclerosis genetics, The Lancet Neurology, vol.13, issue.7, pp.700-709, 2014.
DOI : 10.1016/S1474-4422(14)70041-9

D. A. Schubert, S. Gordo, J. J. Sabatino, S. Vardhana, E. Gagnon et al., Self-reactive human CD4 T cell clones form unusual immunological synapses, The Journal of Experimental Medicine, vol.9, issue.2, pp.335-352, 2012.
DOI : 10.1016/j.immuni.2008.08.011

A. K. Sewell, Why must T cells be cross-reactive?, Nature Reviews Immunology, vol.30, issue.9, pp.669-677, 2012.
DOI : 10.1016/j.immuni.2008.11.011

K. Siewert, J. Malotka, N. Kawakami, H. Wekerle, R. Hohlfeld et al., Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides, Nature Medicine, vol.23, issue.5, pp.824-828, 2012.
DOI : 10.1016/0092-8674(81)90282-8

C. Skulina, S. Schmidt, K. Dornmair, H. Babbe, A. Roers et al., Multiple sclerosis: Brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood, Proceedings of the National Academy of Sciences, vol.23, issue.3, pp.2428-2433, 2004.
DOI : 10.1038/15525

M. Soilu-hänninen, M. Laaksonen, I. Laitinen, J. Erälinna, E. Lilius et al., A longitudinal study of serum 25-hydroxyvitamin D and intact parathyroid hormone levels indicate the importance of vitamin D and calcium homeostasis regulation in multiple sclerosis, Journal of Neurology, Neurosurgery & Psychiatry, vol.79, issue.2, pp.152-157, 2008.
DOI : 10.1136/jnnp.2006.105320

J. M. Soos, M. G. Mujtaba, J. Schiffenbauer, B. A. Torres, J. et al., Intramolecular epitope spreading induced by staphylococcal enterotoxin superantigen reactivation of experimental allergic encephalomyelitis, Journal of Neuroimmunology, vol.123, issue.1-2, pp.30-34, 2002.
DOI : 10.1016/S0165-5728(01)00476-3

R. Srivastava, M. Aslam, S. R. Kalluri, L. Schirmer, D. Buck et al., Potassium Channel KIR4.1 as an Immune Target in Multiple Sclerosis, New England Journal of Medicine, vol.367, issue.2, pp.115-123, 2012.
DOI : 10.1056/NEJMoa1110740

B. Stockinger, M. Veldhoen, M. , and B. , Th17 T cells: Linking innate and adaptive immunity, Seminars in Immunology, vol.19, issue.6, pp.353-361, 2007.
DOI : 10.1016/j.smim.2007.10.008

F. Tilloy, E. Treiner, S. H. Park, C. Garcia, F. Lemonnier et al., An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals, J. Exp, 1999.

A. Windhagen, J. Newcombe, F. Dangond, C. Strand, M. N. Woodroofe et al., Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions, Journal of Experimental Medicine, vol.182, issue.6, 1985.
DOI : 10.1084/jem.182.6.1985

K. W. Wucherpfennig and D. Sethi, T cell receptor recognition of self and foreign antigens in the induction of autoimmunity, Seminars in Immunology, vol.23, issue.2, pp.84-91, 2011.
DOI : 10.1016/j.smim.2011.01.007

Y. Yin, Y. Li, and R. A. Mariuzza, Structural basis for self-recognition by autoimmune T-cell receptors, Immunological Reviews, vol.275, issue.1, pp.32-48, 2012.
DOI : 10.1074/jbc.275.1.312

A. Zandian, B. Forsström, A. Häggmark-månberg, J. M. Schwenk, M. Uhlén et al., Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy, Journal of Proteome Research, vol.16, issue.3, pp.1300-1314, 2017.
DOI : 10.1021/acs.jproteome.6b00916

Y. C. Zang, S. Li, V. M. Rivera, J. Hong, R. R. Robinson et al., Increased CD8+ Cytotoxic T Cell Responses to Myelin Basic Protein in Multiple Sclerosis, The Journal of Immunology, vol.172, issue.8, pp.5120-5127, 1950.
DOI : 10.4049/jimmunol.172.8.5120