M. Ali, L. Dondaine, A. Adolle, C. Sampaio, F. Chotard et al., Anticancer Agents: Does a Phosphonium Behave Like a Gold(I) Phosphine Complex? Let a ???Smart??? Probe Answer!, Journal of Medicinal Chemistry, vol.58, issue.11, pp.4521-4528, 2015.
DOI : 10.1021/acs.jmedchem.5b00480

S. M. Ansell, Targeting immune checkpoints in lymphoma, Current Opinion in Hematology, vol.22, pp.337-342, 2015.
DOI : 10.1097/MOH.0000000000000158

L. Apetoh, F. Ghiringhelli, A. Tesniere, A. Criollo, C. Ortiz et al., The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy, Immunological Reviews, vol.10, issue.1, pp.47-59, 2007.
DOI : 10.1016/j.jim.2004.03.013

L. Apetoh, F. Ghiringhelli, A. Tesniere, M. Obeid, C. Ortiz et al., Toll-like receptor 4???dependent contribution of the immune system to anticancer chemotherapy and radiotherapy, Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy, pp.1050-1059, 2007.
DOI : 10.4049/jimmunol.173.1.307

URL : https://hal.archives-ouvertes.fr/hal-00316924

L. Apetoh, G. Mignot, T. Panaretakis, G. Kroemer, and L. Zitvogel, Immunogenicity of anthracyclines: moving towards more personalized medicine, Trends in Molecular Medicine, vol.14, issue.4, pp.141-151, 2008.
DOI : 10.1016/j.molmed.2008.02.002

O. Arrieta, M. Blake, M. D. De-la-mata-moya, F. Corona, J. Turcott et al., Phase II study. Concurrent chemotherapy and radiotherapy with nitroglycerin in locally advanced non-small cell lung cancer, Radiotherapy and Oncology, vol.111, issue.2, pp.311-315, 2014.
DOI : 10.1016/j.radonc.2014.01.021

C. Aschele, F. Bergamo, and S. Lonardi, Chemotherapy for operable and advanced colorectal cancer, Cancer Treatment Reviews, vol.35, issue.6, pp.509-516, 2009.
DOI : 10.1016/j.ctrv.2009.04.003

A. Bal-price, J. Gartlon, and G. C. Brown, Nitric oxide stimulates PC12 cell proliferation via cGMP and inhibits at higher concentrations mainly via energy depletion, Nitric Oxide, vol.14, issue.3, pp.238-246, 2006.
DOI : 10.1016/j.niox.2005.10.002

A. Bettaieb, S. Plenchette, C. Paul, V. Laurens, S. Romagny et al., S- Nitrosylation in Cancer Cells : To Prevent or to Cause? In Nitric Oxide and Cancer, Pathogenesis and Therapy, 2015.

L. Bezu, L. C. Gomes-de-silva, H. Dewitte, K. Breckpot, J. Fucikova et al., Combinatorial Strategies for the Induction of Immunogenic Cell Death, Frontiers in Immunology, vol.6, p.187, 2015.
DOI : 10.3389/fimmu.2015.00187

URL : https://hal.archives-ouvertes.fr/hal-01215586

C. Bogdan, Nitric oxide and the immune response, Nature Immunology, vol.14, issue.11, pp.907-916, 2001.
DOI : 10.1038/ni1001-907

R. Boina-ali, M. Cortier, N. Decologne, C. Racoeur-godard, C. Seignez et al., Activation of Akt by the Mammalian Target of Rapamycin Complex 2 Renders Colon Cancer Cells Sensitive to Apoptosis Induced by Nitric Oxide and Akt Inhibitor, J Carcinog Mutagen, vol.8, p.4, 2013.

C. Bokemeyer, C. H. Köhne, F. Ciardiello, H. J. Lenz, V. Heinemann et al., FOLFOX4 plus cetuximab treatment and RAS mutations in colorectal cancer, European Journal of Cancer, vol.51, issue.10, pp.1243-1252, 2015.
DOI : 10.1016/j.ejca.2015.04.007

D. M. Goldberg, A. Pardoll, J. M. Gupta, and . Wigginton, Safety and activity of anti-PD-L1 antibody in patients with advanced cancer, N Engl J Med, vol.366, pp.2455-2465, 2012.

A. J. Burke, F. J. Sullivan, F. J. Giles, and S. A. Glynn, The yin and yang of nitric oxide in cancer progression, Carcinogenesis, vol.34, issue.3, pp.503-512, 2013.
DOI : 10.1093/carcin/bgt034

M. Bustin, Regulation of DNA-Dependent Activities by the Functional Motifs of the High-Mobility-Group Chromosomal Proteins, Molecular and Cellular Biology, vol.19, issue.8, pp.5237-5246, 1999.
DOI : 10.1128/MCB.19.8.5237

G. Aucouturier, C. Pierron, L. Garrido, G. Zitvogel, and . Kroemer, Caspasedependent immunogenicity of doxorubicin-induced tumor cell death, J Exp Med, vol.202, pp.1691-1701, 2005.

M. P. Chao, S. Jaiswal, R. Weissman-tsukamoto, A. A. Alizadeh, A. J. Gentles et al., Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47, Science Translational Medicine, vol.3, issue.2, pp.63-94, 2010.
DOI : 10.1016/S1535-6108(03)00028-X

C. F. Chen, M. Y. Huang, C. J. Huang, C. H. Wu, Y. S. Yeh et al., A observational study of the efficacy and safety of capecitabine versus bolus infusional 5-fluorouracil in pre-operative chemoradiotherapy for locally advanced rectal cancer, International Journal of Colorectal Disease, vol.50, issue.7, pp.727-736, 2012.
DOI : 10.1007/s10350-007-0233-6

Z. Chen, M. W. Foster, J. Zhang, L. Mao, H. A. Rockman et al., An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation, Proceedings of the National Academy of Sciences, vol.579, issue.17, pp.12159-12164, 2005.
DOI : 10.1016/j.febslet.2005.05.078

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1189320

Z. Chen, J. Zhang, and J. S. Stamler, Identification of the enzymatic mechanism of nitroglycerin bioactivation, Proceedings of the National Academy of Sciences, vol.129, issue.1-2, pp.8306-8311, 2002.
DOI : 10.1016/S0009-2797(00)00211-8

C. Chung and M. Christianson, Predictive and prognostic biomarkers with therapeutic targets in breast, colorectal, and non-small cell lung cancers: A systemic review of current development, evidence, and recommendation, Journal of Oncology Pharmacy Practice, vol.27, issue.2, pp.11-28, 2014.
DOI : 10.1056/NEJMoa0808268

P. Chung, T. Cook, K. Liu, Y. Vodovotz, R. Zamora et al., Overexpression of the human inducible nitric oxide synthase gene enhances radiation-induced apoptosis in colorectal cancer cells via a caspase-dependent mechanism, Nitric Oxide, vol.8, issue.2, pp.119-126, 2003.
DOI : 10.1016/S1089-8603(02)00147-7

P. Comella, R. Casaretti, A. Avallone, and L. Franco, Optimizing the management of metastatic colorectal cancer, Critical Reviews in Oncology/Hematology, vol.75, issue.1, pp.15-26, 2010.
DOI : 10.1016/j.critrevonc.2009.09.008

M. Cortier, R. Boina-ali, C. Racoeur, C. Paul, E. Solary et al., H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway, Oncotarget, vol.6, issue.9, pp.6877-6886, 2015.
DOI : 10.18632/oncotarget.3124

A. De-gramont, A. Figer, M. Seymour, M. Homerin, A. Hmissi et al., Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer, Journal of Clinical Oncology, vol.18, issue.16, pp.2938-2947, 2000.
DOI : 10.1200/JCO.2000.18.16.2938

W. De-roock, B. Claes, D. Bernasconi, J. De-schutter, B. Biesmans et al., Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis, Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis, pp.753-762, 2010.
DOI : 10.1016/S1470-2045(10)70130-3

M. Degirmenci, B. Karaca, G. Gorumlu, R. Durusoy, G. Demir-piskin et al., Efficacy and safety of bevacizumab plus capecitabine and irinotecan regimen for metastatic colorectal cancer, Medical Oncology, vol.15, issue.4, pp.585-591, 2010.
DOI : 10.1007/s12032-009-9253-5

V. T. Devita and E. Chu, A History of Cancer Chemotherapy, Cancer Research, vol.68, issue.21, pp.8643-8653, 2008.
DOI : 10.1158/0008-5472.CAN-07-6611

A. M. Dingemans, H. J. Groen, G. J. Herder, J. A. Stigt, E. F. Smit et al., Aerts, and N.s. group. 2015. A randomized phase II study comparing paclitaxel-carboplatin-bevacizumab with or without nitroglycerin patches in patients with stage IV nonsquamous nonsmall-cell lung cancer, Ann Oncol, vol.26, pp.122286-2293

L. Dondaine, D. Escurado, M. Ali, P. Richard, F. Denat et al., Coumarin-Phosphine-Based Smart Probes for Tracking Biologically Relevant Metal Complexes: From Theoretical to Biological Investigations Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors, European Journal of Inorganic Chemistry Duraiswamy, Cancer Res, vol.73, pp.3591-3603, 2013.

L. Angevin and . Zitvogel, Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial, J Transl Med, vol.3, p.10, 2005.
URL : https://hal.archives-ouvertes.fr/inserm-00092539

C. B. Evig, E. E. Kelley, C. J. Weydert, Y. Chu, G. R. Buettner et al., Endogenous production and exogenous exposure to nitric oxide augment doxorubicin cytotoxicity for breast cancer cells but not cardiac myoblasts, Nitric Oxide, vol.10, issue.3, pp.119-129, 2004.
DOI : 10.1016/j.niox.2004.03.006

J. M. Extra, M. Espie, F. Calvo, C. Ferme, L. Mignot et al., Phase I study of oxaliplatin in patients with advanced cancer, Cancer Chemotherapy and Pharmacology, vol.12, issue.4, pp.299-303, 1990.
DOI : 10.1007/BF00684890

J. Ferlay, I. Soerjomataram, R. Dikshit, S. Eser, C. Mathers et al., Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012, International Journal of Cancer, vol.13, issue.5, pp.359-386, 2015.
DOI : 10.1016/S1470-2045(12)70137-7

M. C. Franco and A. G. Estévez, Tyrosine nitration as mediator of cell death, Cellular and Molecular Life Sciences, vol.31, issue.4, pp.3939-3950, 2014.
DOI : 10.1016/S0891-5849(01)00600-1

L. J. Frederiksen, R. Sullivan, L. R. Maxwell, S. K. Macdonald-goodfellow, M. A. Adams et al., Chemosensitization of Cancer In vitro and In vivo by Nitric Oxide Signaling, Clinical Cancer Research, vol.13, issue.7, pp.2199-2206, 2007.
DOI : 10.1158/1078-0432.CCR-06-1807

R. F. Furchgott and J. V. Zawadzki, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature, vol.265, issue.5789, pp.373-376, 1980.
DOI : 10.1161/01.RES.34.3.317

T. F. Gajewski, H. Schreiber, and Y. X. Fu, Innate and adaptive immune cells in the tumor microenvironment, Nature Immunology, vol.179, issue.10, pp.1014-1022, 2013.
DOI : 10.1016/j.ijrobp.2012.12.025

L. Galluzzi, A. Buqué, O. Kepp, L. Zitvogel, G. Kroemer-galon et al., Immunogenic cell death in cancer and infectious disease Type, density, and location of immune cells within human colorectal tumors predict clinical outcome, Nat Rev Immunol Science, vol.313, pp.1960-1964, 2006.

F. Ghiringhelli, L. Apetoh, A. Tesniere, L. Aymeric, Y. Ma et al., Activation of the NLRP3 inflammasome in dendritic cells induces IL-1?????dependent adaptive immunity against tumors, Activation of the NLRP3 inflammasome in dendritic cells induces IL-1beta-dependent adaptive immunity against tumors, pp.1170-1178, 2009.
DOI : 10.4049/jimmunol.172.6.3399

URL : https://hal.archives-ouvertes.fr/hal-00419823

A. E. Giuliano, D. M. Kirgan, J. M. Guenther, and D. L. Morton, Lymphatic Mapping and Sentinel Lymphadenectomy for Breast Cancer, Annals of Surgery, vol.220, issue.3, pp.391-398, 1994.
DOI : 10.1097/00000658-199409000-00015

E. B. Golden and L. Apetoh, Radiotherapy and Immunogenic Cell Death, Seminars in Radiation Oncology, vol.25, issue.1, pp.11-17, 2015.
DOI : 10.1016/j.semradonc.2014.07.005

URL : http://doi.org/10.1016/j.semradonc.2014.07.005

G. H. Goodwin, C. Sanders, and E. W. Johns, A New Group of Chromatin-Associated Proteins with a High Content of Acidic and Basic Amino Acids, European Journal of Biochemistry, vol.4, issue.1, pp.14-19, 1973.
DOI : 10.1042/bj0920055

N. Gould, P. T. Doulias, M. Tenopoulou, K. Raju, and H. Ischiropoulos, -Nitrosylation, Journal of Biological Chemistry, vol.267, issue.37, pp.26473-26479, 2013.
DOI : 10.1074/mcp.R111.013037

URL : https://hal.archives-ouvertes.fr/inria-00621263

G. P. Gupta and J. Massagué, Cancer Metastasis: Building a Framework, Cell, vol.127, issue.4, pp.679-695, 2006.
DOI : 10.1016/j.cell.2006.11.001

URL : http://doi.org/10.1016/j.cell.2006.11.001

B. Gustavsson, G. Carlsson, D. Machover, N. Petrelli, A. Roth et al., A Review of the Evolution of Systemic Chemotherapy in the Management of Colorectal Cancer, Clinical Colorectal Cancer, vol.14, issue.1, pp.1-10, 2015.
DOI : 10.1016/j.clcc.2014.11.002

O. Hamid, C. Robert, A. Daud, F. S. Hodi, W. J. Hwu et al., Safety and Tumor Responses with Lambrolizumab (Anti???PD-1) in Melanoma, New England Journal of Medicine, vol.369, issue.2, pp.134-144, 2013.
DOI : 10.1056/NEJMoa1305133

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4126516

D. Hanahan and R. A. Weinberg, The Hallmarks of Cancer, Cell, vol.100, issue.1, pp.57-70, 2000.
DOI : 10.1016/S0092-8674(00)81683-9

D. Hanahan and R. A. Weinberg, Hallmarks of Cancer: The Next Generation, Cell, vol.144, issue.5, pp.646-674, 2011.
DOI : 10.1016/j.cell.2011.02.013

H. W. Herr, V. P. Laudone, R. A. Badalament, H. F. Oettgen, P. C. Sogani et al., Bacillus Calmette-Gu??rin therapy alters the progression of superficial bladder cancer., Journal of Clinical Oncology, vol.6, issue.9, pp.1450-1455, 1988.
DOI : 10.1200/JCO.1988.6.9.1450

V. Hess, R. Winterhalder, R. Von-moos, L. Widmer, P. Stocker et al., Capecitabine and Oxaliplatin Prior and Concurrent to Preoperative Pelvic Radiotherapy in Patients With Locally Advanced Rectal Cancer: Long-Term Outcome Nitric oxide and cancer therapy: the emperor has NO clothes, Clin Colorectal Cancer Hickok J.R. Curr Pharm Des, vol.16, pp.381-391, 2010.

R. D. Hofheinz, F. Wenz, S. Post, A. Matzdorff, S. Laechelt et al., Chemoradiotherapy with capecitabine versus fluorouracil for locally advanced rectal cancer: a randomised, multicentre, non-inferiority, phase 3 trial, The Lancet Oncology, vol.13, issue.6, pp.579-588, 2012.
DOI : 10.1016/S1470-2045(12)70116-X

N. Hogg, Biological chemistry and clinical potential of S-nitrosothiols, Free Radical Biology and Medicine, vol.28, issue.10, pp.1478-1486, 2000.
DOI : 10.1016/S0891-5849(00)00248-3

F. Hollande, J. Pannequin, and D. Joubert, The long road to colorectal cancer therapy: Searching for the right signals, Drug Resistance Updates, vol.13, issue.1-2, pp.44-56, 2010.
DOI : 10.1016/j.drup.2009.01.002

S. Huerta, G. Baay-guzman, C. R. Gonzalez-bonilla, E. H. Livingston, S. Huerta-yepez et al., In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF, Nitric Oxide, vol.20, issue.3, pp.182-194, 2009.
DOI : 10.1016/j.niox.2008.11.006

R. O. Hynes, The Extracellular Matrix: Not Just Pretty Fibrils, Science, vol.284, issue.25, pp.1216-1219, 2009.
DOI : 10.1074/jbc.M809348200

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3536535

M. F. Häfner and J. Debus, Radiotherapy for Colorectal Cancer: Current Standards and Future Perspectives, Visceral Medicine, vol.32, issue.3, pp.172-177, 2016.
DOI : 10.1159/000446486

L. J. Ignarro, G. M. Buga, K. S. Wood, R. E. Byrns, and G. Chaudhuri, Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide., Proceedings of the National Academy of Sciences, vol.84, issue.24, pp.9265-9269, 1987.
DOI : 10.1073/pnas.84.24.9265

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC299734/pdf

H. Illum, D. H. Wang, J. E. Dowell, W. J. Hittson, J. R. Torrisi et al., Phase I dose escalation trial of??nitroglycerin in addition to??5-fluorouracil and radiation therapy for neoadjuvant treatment of operable rectal cancer, Surgery, vol.158, issue.2, pp.460-465, 2015.
DOI : 10.1016/j.surg.2015.04.007

N. Isambert, P. Fumoleau, C. Paul, C. Ferrand, S. Zanetta et al., Phase I study of OM-174, a lipid A analogue, with assessment of immunological response, in patients with refractory solid tumors, BMC Cancer, vol.563, issue.1, p.172, 2013.
DOI : 10.1016/j.ejphar.2007.02.018

URL : https://hal.archives-ouvertes.fr/inserm-00813522

. Wale, Pathologic response to neoadjuvant treatment in locally advanced rectal cancer and impact on outcome, J Gastrointest Oncol, vol.7, pp.603-608, 2016.

A. Jemal, F. Bray, M. M. Center, J. Ferlay, E. Ward et al., Global cancer statistics, CA: A Cancer Journal for Clinicians, vol.82, issue.19 suppl, pp.69-90, 2011.
DOI : 10.1097/00002030-199912240-00012

R. Jover, P. Zapater, A. Castells, X. Llor, M. Andreu et al., The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status, European Journal of Cancer, vol.45, issue.3, pp.365-373, 2009.
DOI : 10.1016/j.ejca.2008.07.016

M. Kalia, Biomarkers for personalized oncology: recent advances and future challenges, Metabolism, vol.64, issue.3, pp.16-21, 2015.
DOI : 10.1016/j.metabol.2014.10.027

S. Kawanishi, Y. Hiraku, S. Pinlaor, and N. Ma, Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis, Biological Chemistry, vol.313, issue.4, pp.365-372, 2006.
DOI : 10.1254/jphs.CRJ05004X

H. Workenhe, W. X. Yang, L. Zong, G. Zitvogel, L. Kroemer et al., Consensus guidelines for the detection of immunogenic cell death, Oncoimmunology, vol.3, p.955691, 2014.

J. E. Kim and S. R. Tannenbaum, -Nitrosation Regulates the Activation of Endogenous Procaspase-9 in HT-29 Human Colon Carcinoma Cells, Journal of Biological Chemistry, vol.3, issue.11, pp.9758-9764, 2004.
DOI : 10.1038/35055152

URL : https://hal.archives-ouvertes.fr/hal-00900969

E. Klemenska and A. Beresewicz, Bioactivation of organic nitrates and the mechanism of nitrate tolerance, Cardiol J, vol.16, pp.11-19, 2009.

A. Y. Kolyada, N. Savikovsky, and N. E. Madias, Transcriptional Regulation of the Human iNOS Gene in Vascular-Smooth-Muscle Cells and Macrophages: Evidence for Tissue Specificity, Biochemical and Biophysical Research Communications, vol.220, issue.3, pp.600-605, 1996.
DOI : 10.1006/bbrc.1996.0449

G. Kroemer, L. Galluzzi, O. Kepp, and L. Zitvogel, Immunogenic Cell Death in Cancer Therapy, Annual Review of Immunology, vol.31, issue.1, pp.51-72, 2013.
DOI : 10.1146/annurev-immunol-032712-100008

S. Ladoire, D. Hannani, M. Vetizou, C. Locher, L. Aymeric et al., Cell-Death-Associated Molecular Patterns As Determinants of Cancer Immunogenicity, Antioxidants & Redox Signaling, vol.20, issue.7, pp.1098-1116, 2014.
DOI : 10.1089/ars.2012.5133

L. Lafay and R. Ancellin, Food intake and colorectal, pp.262-70, 2015.

L. Leon, J. F. Jeannin, and A. Bettaieb, Post-translational modifications induced by nitric oxide (NO): Implication in cancer cells apoptosis, Nitric Oxide, vol.19, issue.2, pp.77-83, 2008.
DOI : 10.1016/j.niox.2008.04.014

L. Leon-bollotte, S. Subramaniam, O. Cauvard, S. Plenchette-colas, C. Paul et al., S-Nitrosylation of the Death Receptor Fas Promotes Fas Ligand???Mediated Apoptosis in Cancer Cells, Gastroenterology, vol.140, issue.7, 2001.
DOI : 10.1053/j.gastro.2011.02.053

URL : https://hal.archives-ouvertes.fr/hal-00680824

N. Lescut, A. Lepinoy, B. Schipman, T. Cerda, V. Guimas et al., Chimioradioth??rapie pr??op??ratoire du cancer du rectum??: exp??rience d???un centre, Cancer/Radioth??rapie, vol.19, issue.2, pp.98-105, 2015.
DOI : 10.1016/j.canrad.2014.11.011

C. C. Liu, P. Leclair, M. Monajemi, L. M. Sly, G. S. Reid et al., ??-Integrin expression and function modulates presentation of cell surface calreticulin, Cell Death and Disease, vol.9, issue.6, p.2268
DOI : 10.1083/jcb.134.1.227

D. B. Longley, D. P. Harkin, and P. G. Johnston, 5-Fluorouracil: mechanisms of action and clinical strategies, Nature Reviews Cancer, vol.3, issue.5, pp.330-338, 2003.
DOI : 10.1038/nrc1074

P. Taylor, E. Van-endert, M. J. Solary, L. Smyth, G. Zitvogel et al., Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells, Immunity, vol.38, pp.729-741, 2013.

L. Kroemer and . Zitvogel, Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy, J Exp Med, vol.208, pp.491-503, 2011.
URL : https://hal.archives-ouvertes.fr/pasteur-00576679

T. Marsh, K. Pietras, and S. S. Mcallister, Fibroblasts as architects of cancer pathogenesis, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1832, issue.7, pp.1070-1078, 2013.
DOI : 10.1016/j.bbadis.2012.10.013

URL : http://doi.org/10.1016/j.bbadis.2012.10.013

H. E. Marshall and J. S. Stamler, Inhibition of NF-??B by S-Nitrosylation, Biochemistry, vol.40, issue.6, pp.1688-1693, 2001.
DOI : 10.1021/bi002239y

I. Martins, O. Kepp, F. Schlemmer, S. Adjemian, M. Tailler et al., Restoration of the immunogenicity of cisplatin-induced cancer cell death by endoplasmic reticulum stress, Oncogene, vol.335, issue.10, pp.1147-1158, 2011.
DOI : 10.1016/j.cell.2010.02.015

I. Martins, Y. Wang, M. Michaud, Y. Ma, A. Q. Sukkurwala et al., Molecular mechanisms of ATP secretion during immunogenic cell death, Cell Death and Differentiation, vol.12, issue.1, pp.79-91, 2014.
DOI : 10.1007/s10495-007-0720-1

A. Millet, A. Bettaieb, F. Renaud, L. Prevotat, A. Hammann et al., Influence of the nitric oxide donor glyceryl trinitrate on apoptotic pathways in human colon cancer cells, Gastroenterology, vol.123, issue.1, pp.235-246, 2002.
DOI : 10.1053/gast.2002.34310

S. Mocellin, V. Bronte, and D. Nitti, Nitric oxide, a double edged sword in cancer biology: Searching for therapeutic opportunities, Medicinal Research Reviews, vol.62, issue.481, pp.317-352, 2007.
DOI : 10.1016/S0002-9440(10)63835-7

S. Moncada and A. Higgs, The L-arginine-nitric oxide pathway, N Engl J Med, vol.329, pp.2002-2012, 1993.

R. Nakato, Y. Ohkubo, A. Konishi, M. Shibata, Y. Kaneko et al., Regulation of the unfolded protein response via S-nitrosylation of sensors of endoplasmic reticulum stress, Scientific Reports, vol.1292, issue.9961, p.14812, 2015.
DOI : 10.1007/978-1-4939-2522-3_14

M. Obeid, A. Tesniere, F. Ghiringhelli, G. M. Fimia, L. Apetoh et al., Calreticulin exposure dictates the immunogenicity of cancer cell death, Nature Medicine, vol.279, issue.1, pp.54-61, 2007.
DOI : 10.1038/nm1523

URL : https://hal.archives-ouvertes.fr/inserm-00451702

T. Panaretakis, N. Joza, N. Modjtahedi, A. Tesniere, I. Vitale et al., The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death, Cell Death and Differentiation, vol.21, issue.9, pp.1499-1509, 2008.
DOI : 10.1007/s00109-007-0214-1

G. Williams and . Kroemer, Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death, EMBO J, vol.28, pp.578-590, 2009.

D. M. Pardoll, The blockade of immune checkpoints in cancer immunotherapy, Nature Reviews Cancer, vol.12, issue.4, pp.252-264, 2012.
DOI : 10.1038/nrc3237

S. Plenchette, S. Romagny, V. Laurens, and A. Bettaieb, S-nitrosylation in TNF superfamily signaling pathway: Implication in cancer, Redox Biology, vol.6, pp.507-515, 2015.
DOI : 10.1016/j.redox.2015.08.019

L. Prévotat, R. Filomenko, E. Solary, J. F. Jeannin, and A. Bettaieb, Nitric Oxide-Induced Down-Regulation of ??-Catenin in Colon Cancer Cells by a Proteasome-Independent Specific Pathway, Gastroenterology, vol.131, issue.4, pp.1142-1152, 2006.
DOI : 10.1053/j.gastro.2006.07.017

N. L. Reynaert, K. Ckless, S. H. Korn, N. Vos, A. S. Guala et al., Nitric oxide represses inhibitory ??B kinase through S-nitrosylation, Proceedings of the National Academy of Sciences, vol.6, issue.2, pp.8945-8950, 2004.
DOI : 10.1074/jbc.M001644200

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC428452

C. M. Ribic, D. J. Sargent, M. J. Moore, S. N. Thibodeau, A. J. French et al., Tumor Microsatellite-Instability Status as a Predictor of Benefit from Fluorouracil-Based Adjuvant Chemotherapy for Colon Cancer, New England Journal of Medicine, vol.349, issue.3, pp.247-257, 2003.
DOI : 10.1056/NEJMoa022289

C. Rébé and F. Ghiringhelli, Cytotoxic effects of chemotherapy on cancer and immune cells: how can it be modulated to generate novel therapeutic strategies? Future Oncol Senescence of tumor cells induced by oxaliplatin increases the efficiency of a lipid A immunotherapy via the recruitment of neutrophils, Oncotarget, vol.5, pp.11442-11451, 2014.

A. Siegert, C. Rosenberg, W. D. Schmitt, C. Denkert, and S. Hauptmann, Nitric oxide of human colorectal adenocarcinoma cell lines promotes tumour cell invasion, British Journal of Cancer, vol.436, issue.8, pp.1310-1315, 2002.
DOI : 10.1038/bjc.1995.274

D. R. Siemens, J. P. Heaton, M. A. Adams, J. Kawakami, and C. H. Graham, Phase II Study of Nitric Oxide Donor for Men With Increasing Prostate-specific Antigen Level After Surgery or Radiotherapy for Prostate Cancer, Urology, vol.74, issue.4, pp.878-883, 2009.
DOI : 10.1016/j.urology.2009.03.004

R. Sorelle, Nobel Prize Awarded to Scientists for Nitric Oxide Discoveries, Circulation, vol.98, issue.22, pp.2365-2366, 1998.
DOI : 10.1161/01.CIR.98.22.2365

P. Soulié, E. Raymond, S. Brienza, and E. Cvitkovic, [Oxaliplatin: the first DACH platinum in clinical practice], Bull Cancer, vol.84, pp.665-673, 1997.

A. Tesniere, L. Apetoh, F. Ghiringhelli, N. Joza, T. Panaretakis et al., Immunogenic cancer cell death: a key-lock paradigm, Current Opinion in Immunology, vol.20, issue.5, pp.504-511, 2008.
DOI : 10.1016/j.coi.2008.05.007

A. Tesniere, F. Schlemmer, V. Boige, O. Kepp, I. Martins et al., Immunogenic death of colon cancer cells treated with oxaliplatin, Oncogene, vol.177, issue.4, pp.482-491, 2010.
DOI : 10.1172/JCI35180

G. R. Thatcher, A. C. Nicolescu, B. M. Bennett, and V. Toader, Nitrates and no release: contemporary aspects in biological and medicinal chemistry, Free Radical Biology and Medicine, vol.37, issue.8, pp.1122-1143, 2004.
DOI : 10.1016/j.freeradbiomed.2004.06.013

P. Thirion, S. Michiels, J. P. Pignon, M. Buyse, A. C. Braud et al., Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: an updated meta-analysis, J Clin Oncol, vol.22, pp.3766-3775, 2004.

J. O. Thomas and A. A. Travers, HMG1 and 2, and related ???architectural??? DNA-binding proteins, Trends in Biochemical Sciences, vol.26, issue.3, pp.167-174, 2001.
DOI : 10.1016/S0968-0004(01)01801-1

T. L. Taube, H. Mcmiller, A. J. Xu, M. Korman, S. Jure-kunkel et al., Safety, activity, and immune correlates of anti-PD-1 antibody in cancer, N Engl J Med, vol.366, pp.2443-2454, 2012.

T. Uehara, T. Nakamura, D. Yao, Z. Q. Shi, Z. Gu et al., S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration, Nature, vol.304, issue.7092, pp.513-517, 2006.
DOI : 10.1038/nature04782

N. Uehiro, R. Horii, T. Iwase, M. Tanabe, T. Sakai et al., Validation study of the UICC TNM classification of malignant tumors, seventh edition, in breast cancer, Breast Cancer, vol.13, issue.6, pp.748-753, 2014.
DOI : 10.1158/1078-0432.CCR-06-2512

E. Vacchelli, F. Aranda, A. Eggermont, J. Galon, C. Sautès-fridman et al., Trial Watch: Chemotherapy with immunogenic cell death inducers Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer: 12-year follow-up of the multicentre, randomised controlled TME trial, Lancet Oncol, vol.12, pp.575-582, 2011.

F. Vannini, K. Kashfi, and N. Nath, The dual role of iNOS in cancer, Redox Biology, vol.6, pp.334-343, 2015.
DOI : 10.1016/j.redox.2015.08.009

M. D. Vesely, M. H. Kershaw, R. D. Schreiber, and M. J. Smyth, Natural Innate and Adaptive Immunity to Cancer, Annual Review of Immunology, vol.29, issue.1, pp.235-271, 2011.
DOI : 10.1146/annurev-immunol-031210-101324

S. Viaud, C. Théry, S. Ploix, T. Tursz, V. Lapierre et al., Dendritic Cell-Derived Exosomes for Cancer Immunotherapy: What's Next?, Cancer Research, vol.70, issue.4, pp.1281-1285, 2010.
DOI : 10.1158/0008-5472.CAN-09-3276

M. K. Washington, Colorectal carcinoma: selected issues in pathologic examination and staging and determination of prognostic factors, Arch Pathol Lab Med, vol.132, pp.1600-1607, 2008.

N. P. West, W. Hohenberger, K. Weber, A. Perrakis, P. J. Finan et al., Complete Mesocolic Excision With Central Vascular Ligation Produces an Oncologically Superior Specimen Compared With Standard Surgery for Carcinoma of the Colon, Journal of Clinical Oncology, vol.28, issue.2, pp.272-278, 2010.
DOI : 10.1200/JCO.2009.24.1448

T. Yamazaki, D. Hannani, V. Poirier-colame, S. Ladoire, C. Locher et al., Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists, Cell Death and Differentiation, vol.261, issue.1, pp.69-78, 2014.
DOI : 10.1016/0304-4165(72)90340-6

H. Yasuda, M. Yamaya, K. Nakayama, T. Sasaki, S. Ebihara et al., Randomized Phase II Trial Comparing Nitroglycerin Plus Vinorelbine and Cisplatin With Vinorelbine and Cisplatin Alone in Previously Untreated Stage IIIB/IV Non???Small-Cell Lung Cancer, Journal of Clinical Oncology, vol.24, issue.4, pp.688-694, 2006.
DOI : 10.1200/JCO.2005.04.0436

J. H. Youn and J. S. Shin, Nucleocytoplasmic Shuttling of HMGB1 Is Regulated by Phosphorylation That Redirects It toward Secretion, The Journal of Immunology, vol.177, issue.11, pp.7889-7897, 2006.
DOI : 10.4049/jimmunol.177.11.7889

L. Zitvogel, L. Apetoh, F. Ghiringhelli, and G. Kroemer, Immunological aspects of cancer chemotherapy, Nature Reviews Immunology, vol.313, issue.1, pp.59-73, 2008.
DOI : 10.4049/jimmunol.172.4.2039

P. Bettaieb, V. Le-gendre, C. Laurens, C. Goze, E. Paul et al., Anticancer Agents: Does a Phosphonium Behave Like a Gold(I) Phosphine Complex? Let a "Smart, Probe Answer! J Med Chem, vol.58, pp.4521-4528, 2015.