Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT, Journal of Experimental & Clinical Cancer Research, vol.28, issue.1, p.147, 2009. ,
DOI : 10.1186/1756-9966-28-147
Molecular biology of the cell Available at, 2002. ,
In vitro display technologies: novel developments and applications, Current Opinion in Biotechnology, vol.12, issue.4, pp.400-405, 2001. ,
DOI : 10.1016/S0958-1669(00)00234-2
Intracellular neutralization of SV40 tumor antigens following microinjection of specific antibody, Cell, vol.19, issue.3, pp.627-635, 1980. ,
DOI : 10.1016/S0092-8674(80)80039-0
Phage display technology: clinical applications and recent innovations, Clinical Biochemistry, vol.35, issue.6, pp.425-445, 2002. ,
DOI : 10.1016/S0009-9120(02)00343-0
Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease, New England Journal of Medicine, vol.348, issue.7, pp.601-608, 2003. ,
DOI : 10.1056/NEJMoa020888
Antibody constructs in cancer therapy, Cancer, vol.15, issue.2, pp.170-179, 2007. ,
DOI : 10.1002/cncr.22402
Expression and targeting of intracellular antibodies in mammalian cells. the The European, Molecular Biology Organization Journal, vol.9, issue.1, pp.101-108, 1990. ,
Single-chain antigen-binding proteins, Science, vol.242, issue.4877, pp.423-426, 1988. ,
DOI : 10.1126/science.3140379
Yeast surface display for screening combinatorial polypeptide libraries, Nature Biotechnology, vol.4, issue.6, pp.553-557, 1997. ,
DOI : 10.1016/0378-1119(88)90185-0
Novel highly efficient intrabody mediates complete inhibition of cell surface expression of the human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR), Journal of Immunological Methods, vol.300, issue.1-2, pp.146-159, 2005. ,
DOI : 10.1016/j.jim.2005.03.007
Production of functional chimaeric mouse/human antibody, Nature, vol.103, issue.5995, pp.643-646, 1984. ,
DOI : 10.1038/312643a0
Purification of bacterially expressed single chain Fv antibodies for clinical applications using metal chelate chromatography, Journal of Immunological Methods, vol.179, issue.1, pp.105-116, 1995. ,
DOI : 10.1016/0022-1759(94)00278-5
Therapeutic antibodies: successes, limitations and hopes for the future, British Journal of Pharmacology, vol.163, issue.2, pp.220-233, 2009. ,
DOI : 10.1111/j.1476-5381.2009.00190.x
Construction of humanized carcinoembryonic antigen specific single chain variable fragment and mitomycin conjugate, World Journal of Gastroenterology, vol.13, issue.43, pp.5765-5770, 2007. ,
DOI : 10.3748/wjg.v13.i43.5765
Intracellular expression of an antibody fragment-neutralizing p21 ras promotes tumor regression, Cancer Research, vol.58, issue.6, pp.1170-1176, 1998. ,
Single-Chain Antibodies in Pancreatic Cancer, Annals of the New York Academy of Sciences, vol.28, issue.1 CELL AND MOLE, pp.263-280, 1999. ,
DOI : 10.1016/S0022-1759(96)00195-0
Requirement of e6ap and the features of human papillomavirus e6 necessary to support degradation of p53, Virology, vol.306, issue.1, pp.87-99, 2003. ,
DOI : 10.1016/S0042-6822(02)00012-0
Suppression of cervical carcinoma cell growth by intracytoplasmic codelivery of anti-oncoprotein E6 antibody and small interfering RNA, Molecular Cancer Therapeutics, vol.6, issue.6, pp.1728-1735, 2007. ,
DOI : 10.1158/1535-7163.MCT-06-0808
antigen selection of camelized, human VH domains with improved protein stability, "Protein Engineering, Design and Selection", vol.9, issue.6, pp.531-537, 1996. ,
DOI : 10.1093/protein/9.6.531
Rituximab Anti-CD20 Monoclonal Antibody Therapy in Non-Hodgkin ' s Lymphoma : Safety and Efficacy of, Clinical Research, vol.18, issue.17, pp.3135-3143, 2000. ,
A Fully Human Antitumor ImmunoRNase Selective for ErbB-2-Positive Carcinomas, Cancer Research, vol.64, issue.14, pp.4870-4874, 2004. ,
DOI : 10.1158/0008-5472.CAN-03-3717
URL : http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.334.4723
Direct in Vivo Screening of Intrabody Libraries Constructed on a Highly Stable Single-chain Framework, Journal of Biological Chemistry, vol.277, issue.47, pp.45075-45085, 2002. ,
DOI : 10.1074/jbc.M205264200
Automated overexpression and isotopic labelling of biologically active oncoproteins in the cyanobacterium Anabaena sp. PCC 7120, Biotechnology and Applied Biochemistry, vol.51, issue.1, pp.51-53, 2008. ,
DOI : 10.1042/BA20070276
URL : https://hal.archives-ouvertes.fr/inserm-00350862
Engineering Stable Cytoplasmic Intrabodies with Designed Specificity, Journal of Molecular Biology, vol.330, issue.2, pp.323-332, 2003. ,
DOI : 10.1016/S0022-2836(03)00530-8
Interaction of oncogenic papillomavirus E6 proteins with fibulin-1, Biochemical and Biophysical Research Communications, vol.296, issue.4, pp.962-969, 2002. ,
DOI : 10.1016/S0006-291X(02)02041-7
Antibody framework residues affecting the conformation of the hypervariable loops, Journal of Molecular Biology, vol.224, issue.2, pp.487-499, 1992. ,
DOI : 10.1016/0022-2836(92)91010-M
in human hepatocellular carcinoma and its clinical significance, World Journal of Gastroenterology, vol.8, issue.4, pp.638-643, 2002. ,
DOI : 10.3748/wjg.v8.i4.638
Human papillomavirus E6 and E7 oncoproteins as risk factors for tumorigenesis, Journal of Biosciences, vol.2, issue.1, pp.113-123, 2009. ,
DOI : 10.1007/s12038-009-0013-7
Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire, Proceedings of the National Academy of Sciences, vol.106, issue.48, pp.20216-20221, 2009. ,
DOI : 10.1073/pnas.0909775106
Introduction to NF-??B: players, pathways, perspectives, Oncogene, vol.52, issue.51, pp.6680-6684, 2006. ,
DOI : 10.1016/0092-8674(88)90035-9
Targetting of the N???terminal domain of the human papillomavirus type 16 E6 oncoprotein with monomeric scFvs blocks the E6???mediated degradation of cellular p53, Journal of Molecular Recognition, vol.12, issue.2, pp.141-152, 1999. ,
DOI : 10.1002/(SICI)1099-1352(199903/04)12:2<141::AID-JMR453>3.3.CO;2-F
A comparison of strategies to stabilize immunoglobulin Fv-fragments, Biochemistry, vol.29, issue.6, pp.1362-1367, 1990. ,
DOI : 10.1021/bi00458a002
Reshaping a therapeutic CD4 antibody., Proceedings of the National Academy of Sciences, vol.88, issue.10, pp.4181-4185, 1991. ,
DOI : 10.1073/pnas.88.10.4181
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC51622
Inhibition of Papillomavirus Protein Function in Cervical Cancer Cells by Intrabody Targeting, Journal of Molecular Biology, vol.355, issue.3, pp.360-378, 2006. ,
DOI : 10.1016/j.jmb.2005.10.077
Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas, Nature Medicine, vol.56, issue.1, pp.96-99, 2000. ,
DOI : 10.1073/pnas.96.12.6999
The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53, Cancer Cell, vol.8, issue.1, pp.75-87, 2005. ,
DOI : 10.1016/j.ccr.2005.06.006
Engineered antibody fragments and the rise of single domains, Nature Biotechnology, vol.10, issue.9, pp.1126-1136, 2005. ,
DOI : 10.1182/blood-2005-03-1153
High avidity scFv multimers; diabodies and triabodies, Journal of Immunological Methods, vol.231, issue.1-2, pp.177-189, 1999. ,
DOI : 10.1016/S0022-1759(99)00157-X
Engineered antibodies, Nature Medicine, vol.168, issue.1, pp.129-134, 2003. ,
DOI : 10.1038/nm0302-295
Protein engineering of antibody binding sites: recovery of specific activity in an anti-digoxin single-chain Fv analogue produced in Escherichia coli., Proceedings of the National Academy of Sciences, vol.85, issue.16, pp.855879-5883, 1988. ,
DOI : 10.1073/pnas.85.16.5879
Comparing antibody and small-molecule therapies for cancer, Nature Reviews Cancer, vol.23, issue.9, pp.714-741, 2006. ,
DOI : 10.1038/nrc1913
From XenoMouse technology to panitumumab, the first fully human antibody product from transgenic mice, Nature Biotechnology, vol.188, issue.10, pp.1134-1143, 2007. ,
DOI : 10.1038/nbt1337
Replacing the complementarity-determining regions in a human antibody with those from a mouse, Nature, vol.312, issue.6069, pp.522-525, 1986. ,
DOI : 10.1038/321522a0
Immunity to adenovirus and adeno-associated viral vectors: implications for gene therapy, Gene Therapy, vol.10, issue.11, pp.955-963, 2003. ,
DOI : 10.1038/sj.gt.3302037
Improving in vivo folding and stability of a single-chain Fv antibody fragment by loop grafting, Protein Engineering Design and Selection, vol.10, issue.8, pp.959-966, 1997. ,
DOI : 10.1093/protein/10.8.959
Expression of a Recombinant Fab Antibody Fragment against Cruzipain, the Major Cysteine Proteinase ofTrypanosoma cruzi, Biochemical and Biophysical Research Communications, vol.253, issue.1, pp.53-58, 1998. ,
DOI : 10.1006/bbrc.1998.9654
Monoclonal antibodies. Hybrid myelomas--a revolution in serology and immunogenetics, The American Journal of Human Genetics, issue.5, pp.31-539, 1979. ,
The OKT3 antibody response study: a multicentre study of human anti-mouse antibody (HAMA) production following OKT3 use in solid organ tranplantation, Transplant Immunology, vol.3, issue.3, pp.212-221, 1995. ,
DOI : 10.1016/0966-3274(95)80027-1
Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein, Proceedings of the National Academy of Sciences, vol.94, issue.21, pp.11612-11616, 1997. ,
DOI : 10.1073/pnas.94.21.11612
Continuous cultures of fused cells secreting antibody of predefined specificity, Nature, vol.3, issue.5517, pp.495-497, 1975. ,
DOI : 10.1038/256495a0
Recombinant bispecific antibodies for the targeting of adenoviruses to CEA-expressing tumour cells: a comparative analysis of bacterially expressed single-chain diabody and tandem scFv, The Journal of Gene Medicine, vol.6, issue.6, pp.642-651, 2004. ,
DOI : 10.1002/jgm.555
Dimeric and trimeric antibodies: high avidity scFvs for cancer targeting, Biomolecular Engineering, vol.18, issue.3, pp.95-108, 2001. ,
DOI : 10.1016/S1389-0344(01)00090-9
Formation of a bispecific antibody by the use of leucine zippers, The Journal of Immunology, vol.148, issue.5, pp.1547-1553, 1992. ,
Will immunogenicity limit the use, efficacy, and future development of therapeutic monoclonal antibodies? Clinical and Diagnostic Laboratory Immunology, pp.365-372, 1994. ,
Binding of human papillomavirus 16 E6 to p53 and E6AP is impaired by monoclonal antibodies directed against the second zinc-binding domain of E6, Journal of General Virology, vol.86, issue.4, pp.1001-1007, 2005. ,
DOI : 10.1099/vir.0.80607-0
URL : https://hal.archives-ouvertes.fr/hal-00129908
Single-chain antibody-mediated gene delivery into ErbB2-positive human breast cancer cells, Cancer Gene Therapy, vol.8, issue.8, pp.555-565, 2001. ,
DOI : 10.1038/sj.cgt.7700337
Intracellular Antibodies (Intrabodies) and Their Therapeutic Potential, Handbook of Experimental Pharmacology, issue.181, pp.343-373, 2008. ,
DOI : 10.1007/978-3-540-73259-4_15
Expression of an antibody fragment at high levels in the bacterial cytoplasm, Journal of Molecular Biology, vol.280, issue.1, pp.117-127, 1998. ,
DOI : 10.1006/jmbi.1998.1840
In vitro folding and thermodynamic stability of an antibody fragment selected in Vivo for high expression levels in Escherichia coli cytoplasm, Journal of Molecular Biology, vol.292, issue.4, pp.921-929, 1999. ,
DOI : 10.1006/jmbi.1999.3105
Protein transduction technology, Journal of Molecular Medicine, vol.6, issue.5, pp.324-328, 2005. ,
DOI : 10.1007/s00109-004-0633-1
Phage antibodies: filamentous phage displaying antibody variable domains, Nature, vol.348, issue.6301, pp.552-554, 1990. ,
DOI : 10.1038/348552a0
A Protein Silencing Switch by Ligand-induced Proteasome-targeting Intrabodies, Journal of Molecular Biology, vol.374, issue.3, pp.641-654, 2007. ,
DOI : 10.1016/j.jmb.2007.09.053
Chimeric human antibody molecules: mouse antigen-binding domains with human constant region domains., Proceedings of the National Academy of Sciences, vol.81, issue.21, pp.816851-6855, 1984. ,
DOI : 10.1073/pnas.81.21.6851
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC392030
High-affinity Antigen Binding by Chelating Recombinant Antibodies (CRAbs), Journal of Molecular Biology, vol.246, issue.3, pp.367-373, 1995. ,
DOI : 10.1006/jmbi.1994.0091
Therapeutic efficacy of anti-ErbB2 immunoliposomes targeted by a phage antibody selected for cellular endocytosis, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol.1591, issue.1-3, pp.109-118, 2002. ,
DOI : 10.1016/S0167-4889(02)00256-2
Structural and Functional Analysis of E6 Oncoprotein: Insights in the Molecular Pathways of Human Papillomavirus-Mediated Pathogenesis, Molecular Cell, vol.21, issue.5, pp.665-678, 2006. ,
DOI : 10.1016/j.molcel.2006.01.024
A humanized antibody that binds to the interleukin 2 receptor., Proceedings of the National Academy of Sciences of the United States of America, pp.10029-10033, 1989. ,
DOI : 10.1073/pnas.86.24.10029
ANTI-GLOBULIN RESPONSES TO RAT AND HUMANIZED CAMPATH-1 MONOCLONAL ANTIBODY USED TO TREAT TRANSPLANT REJECTION1, Transplantation, vol.68, issue.9, pp.1417-1420, 1999. ,
DOI : 10.1097/00007890-199911150-00032
Reshaping human antibodies for therapy, Nature, vol.332, issue.6162, pp.323-327, 1988. ,
DOI : 10.1038/332323a0
Identification of a Universal VHH Framework to Graft Non-canonical Antigen-binding Loops of Camel Single-domain Antibodies, Journal of Molecular Biology, vol.352, issue.3, pp.597-607, 2005. ,
DOI : 10.1016/j.jmb.2005.07.038
Production of Fluorescent Single-Chain Antibody Fragments in Escherichia coli, Protein Expression and Purification, vol.18, issue.2, pp.121-132, 2000. ,
DOI : 10.1006/prep.1999.1185
URL : https://hal.archives-ouvertes.fr/hal-00151170
Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene, Journal of Experimental Medicine, vol.175, issue.1, pp.217-225, 1992. ,
DOI : 10.1084/jem.175.1.217
Nucleocytoplasmic shuttling of antigen in mammalian cells conferred by a soluble versus insoluble single-chain antibody fragment equipped with import/export signals, Experimental Cell Research, vol.286, issue.2, pp.276-287, 2003. ,
DOI : 10.1016/S0014-4827(03)00093-4
URL : https://hal.archives-ouvertes.fr/hal-00192416
Extended half-life upon binding of destabilized intrabodies allows specific detection of antigen in mammalian cells, FEBS Journal, vol.84, issue.11, pp.2722878-2891, 2005. ,
DOI : 10.1111/j.1742-4658.2005.04709.x
URL : https://hal.archives-ouvertes.fr/hal-00129985
Protein production by auto-induction in high-density shaking cultures, Protein Expression and Purification, vol.41, issue.1, pp.207-234, 2005. ,
DOI : 10.1016/j.pep.2005.01.016
Molecular biology of proteasomes, Molecular Biology Reports, vol.348, issue.1, pp.21-26, 1995. ,
DOI : 10.1007/BF00990966
Construction and Expression of Single-Chain Antibody Derived from a New Clone of Monoclonal Antibody Against Human CD14 in CHO Cells, Immunopharmacology and Immunotoxicology, vol.32, issue.4, pp.3-4375, 2007. ,
DOI : 10.1080/08923970701619927
Antibody therapy for rheumatoid arthritis, Current Opinion in Pharmacology, vol.3, issue.3, pp.323-328, 2003. ,
DOI : 10.1016/S1471-4892(03)00032-8
Intracellular antibody-caspase-mediated cell killing: An approach for application in cancer therapy, Proceedings of the National Academy of Sciences, vol.97, issue.22, pp.12266-12271, 2000. ,
DOI : 10.1073/pnas.97.22.12266
Penetration of anticancer drugs through solid tissue: a factor that limits the effectiveness of chemotherapy for solid tumors, Clinical Cancer Research, vol.5, issue.6, pp.1583-1586, 1999. ,
Anti-CD3 monoclonal antibody treatment of patients with CD3-negative tumors: a phase IA/B study, Cancer Research, vol.52, issue.9, pp.2394-2401, 1992. ,
OKT3: a monoclonal anti-human T lymphocyte antibody with potent mitogenic properties, The Journal of Immunology, vol.124, issue.6, pp.2708-2713, 1980. ,
General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold, Journal of Biological Chemistry, vol.284, issue.5, pp.3273-3284, 2009. ,
DOI : 10.1074/jbc.M806889200
Applications of single-chain variable fragment antibodies in therapeutics and diagnostics, Biotechnology Advances, vol.27, issue.4, pp.502-520, 2009. ,
DOI : 10.1016/j.biotechadv.2009.04.004
Single domain antibodies: promising experimental and therapeutic tools in infection and immunity, Medical Microbiology and Immunology, vol.7, issue.2, pp.157-74, 2009. ,
DOI : 10.1007/s00430-009-0116-7
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2714450
The in vivo characteristics of genetically engineered divalent and tetravalent single-chain antibody constructs, Nuclear Medicine and Biology, vol.32, issue.2, pp.157-164, 2005. ,
DOI : 10.1016/j.nucmedbio.2004.11.003
Suppression of Huntington_s disease pathology in Drosophila by human single-chain Fv antibodies, Proceedings of the National Academy of Sciences of the United States of America, pp.11563-11568, 2005. ,
Construction and characterization of a Fab recombinant protein for Japanese encephalitis virus neutralization, Vaccine, vol.23, issue.2, pp.163-171, 2004. ,
DOI : 10.1016/j.vaccine.2004.05.016
Monoclonal Antibodies: A Powerful New Tool in Biology and Medicine, Annual Review of Biochemistry, vol.50, issue.1, pp.657-680, 1981. ,
DOI : 10.1146/annurev.bi.50.070181.003301
A human single-chain Fv intrabody blocks aberrant cellular effects of overexpressed ??-synuclein, Molecular Therapy, vol.10, issue.6, pp.1023-1031, 2004. ,
DOI : 10.1016/j.ymthe.2004.08.019
Cells transfected with a non-neutralizing antibody gene are resistant to HIV infection: targeting the endoplasmic reticulum and trans-Golgi network, The Journal of Immunology, vol.160, issue.3, pp.1489-1496, 1998. ,
Human Papilloma Virus 16 E6 Oncoprotein Inhibits Retinoic X Receptor-mediated Transactivation by Targeting Human ADA3 Coactivator, Journal of Biological Chemistry, vol.277, issue.47, pp.45611-45618, 2002. ,
DOI : 10.1074/jbc.M208447200