Systems pharmacology and genome medicine: a future perspective, Genome Medicine, vol.1, issue.1, 2009. ,
DOI : 10.1186/gm11
URL : http://doi.org/10.1186/gm11
Frequency of cancer in France, Bull Cancer, vol.91, pp.9-14, 2004. ,
Numéro thématique -Journée mondiale sans tabac, Bulletin Epidémiologique Hebdomadaire, vol.1920, pp.209-224, 2010. ,
Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case-control studies, BMJ, vol.321, issue.7257, pp.323-329, 2000. ,
DOI : 10.1136/bmj.321.7257.323
Aberrant Epigenetic Landscape in Cancer: How Cellular Identity Goes Awry, Developmental Cell, vol.19, issue.5, pp.698-711, 2010. ,
DOI : 10.1016/j.devcel.2010.10.005
Epigenetic gene silencing in cancer: the DNA hypermethylome, Human Molecular Genetics, vol.16, issue.R1, pp.50-59, 2007. ,
DOI : 10.1093/hmg/ddm018
The Epigenomics of Cancer, Cell, vol.128, issue.4, pp.683-692, 2007. ,
DOI : 10.1016/j.cell.2007.01.029
Telomeres and telomerase in cancer, Carcinogenesis, vol.31, issue.1, pp.9-18, 2010. ,
DOI : 10.1093/carcin/bgp268
JUNCTIONAL COMPLEXES IN VARIOUS EPITHELIA, The Journal of Cell Biology, vol.17, issue.2, pp.375-412, 1963. ,
DOI : 10.1083/jcb.17.2.375
The early steps of neural crest development, Mechanisms of Development, vol.105, issue.1-2, pp.27-35, 2001. ,
DOI : 10.1016/S0925-4773(01)00394-X
Reassessing Epithelial to Mesenchymal Transition as a Prerequisite for Carcinoma Invasion and Metastasis, Cancer Research, vol.66, issue.17, pp.8319-8326, 2006. ,
DOI : 10.1158/0008-5472.CAN-06-0410
Transforming Growth Factor ??-1 Induces Snail Transcription Factor in Epithelial Cell Lines, Journal of Biological Chemistry, vol.278, issue.23, pp.21113-21123, 2003. ,
DOI : 10.1074/jbc.M211304200
Activation of the Erk Pathway Is Required for TGF-??1-Induced EMT In Vitro, Neoplasia, vol.6, issue.5, pp.603-610, 2004. ,
DOI : 10.1593/neo.04241
Epithelial-Mesenchymal Transitions, Cell, vol.118, issue.3, pp.277-279, 2004. ,
DOI : 10.1016/j.cell.2004.07.011
G1 events and regulation of cell proliferation, Science, vol.246, issue.4930, pp.603-608, 1989. ,
DOI : 10.1126/science.2683075
Dimerization of cell surface receptors in signal transduction, Cell, vol.80, issue.2, pp.213-223, 1995. ,
DOI : 10.1016/0092-8674(95)90404-2
PDGF ??-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex, Cell, vol.61, issue.1, pp.125-133, 1990. ,
DOI : 10.1016/0092-8674(90)90220-9
Transmembrane Receptors and Intracellular Pathways that Control Cell Proliferation, Annual Review of Physiology, vol.54, issue.1, pp.195-210, 1992. ,
DOI : 10.1146/annurev.ph.54.030192.001211
Gene regulation by steroid hormones, Cell, vol.56, issue.3, pp.335-344, 1989. ,
DOI : 10.1016/0092-8674(89)90237-7
Steroid Receptor Family: Structure and Functions, Endocrine Reviews, vol.11, issue.2, pp.201-220, 1990. ,
DOI : 10.1210/edrv-11-2-201
Proglucagon gene expression is regulated by a cyclic AMP-dependent pathway in rat intestine., Proceedings of the National Academy of Sciences, vol.86, issue.11, pp.3953-3957, 1989. ,
DOI : 10.1073/pnas.86.11.3953
The Hallmarks of Cancer, Cell, vol.100, issue.1, pp.57-70, 2000. ,
DOI : 10.1016/S0092-8674(00)81683-9
Hallmarks of Cancer: The Next Generation, Cell, vol.144, issue.5, pp.646-674, 2011. ,
DOI : 10.1016/j.cell.2011.02.013
International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: International Multidisciplinary Classification of Lung Adenocarcinoma: Executive Summary, Proceedings of the American Thoracic Society, vol.8, issue.5, pp.381-385, 2011. ,
DOI : 10.1513/pats.201107-042ST
A Rapid and Sensitive Enzymatic Method for Epidermal Growth Factor Receptor Mutation Screening, Clinical Cancer Research, vol.12, issue.3, pp.751-758, 2006. ,
DOI : 10.1158/1078-0432.CCR-05-2047
Response to Erlotinib in First-Line Treatment of Non???Small-Cell Lung Cancer in a White Male Smoker with Squamous-Cell Histology, Clinical Lung Cancer, vol.8, issue.3, pp.214-216, 2006. ,
DOI : 10.3816/CLC.2006.n.050
Pooled analysis of the prospective trials of gefitinib monotherapy for EGFR-mutant non-small cell lung cancers, Lung Cancer, vol.58, issue.1, pp.95-103, 2007. ,
DOI : 10.1016/j.lungcan.2007.05.017
K-ras as a Target for Lung Cancer Therapy, Journal of Thoracic Oncology, vol.3, issue.6, pp.160-163, 2008. ,
DOI : 10.1097/JTO.0b013e318174dbf9
Comparison of Four Chemotherapy Regimens for Advanced Non???Small-Cell Lung Cancer, New England Journal of Medicine, vol.346, issue.2, pp.92-98, 2002. ,
DOI : 10.1056/NEJMoa011954
Prospective Randomized Trial of Docetaxel Versus Best Supportive Care in Patients With Non???Small-Cell Lung Cancer Previously Treated With Platinum-Based Chemotherapy, Journal of Clinical Oncology, vol.18, issue.10, pp.2095-2103, 2000. ,
DOI : 10.1200/JCO.2000.18.10.2095
Lung Cancer with Epidermal Growth Factor Receptor Exon 20 Mutations Is Associated with Poor Gefitinib Treatment Response, Clinical Cancer Research, vol.14, issue.15, pp.4877-4882, 2008. ,
DOI : 10.1158/1078-0432.CCR-07-5123
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling, Science, vol.316, issue.5827, pp.1039-1043, 2007. ,
DOI : 10.1126/science.1141478
Gefitinib versus docetaxel in previously treated non-small-cell lung cancer (INTEREST): a randomised phase III trial, The Lancet, vol.372, issue.9652, pp.1809-1818, 2008. ,
DOI : 10.1016/S0140-6736(08)61758-4
The EGF receptor: structure, regulation and potential role in malignancy, Cancer Surv, vol.4, pp.767-788, 1985. ,
Epidermal growth factor, J Biol Chem, vol.265, pp.7709-7712, 1990. ,
Growth Factor Receptor Tyrosine Kinases, Annual Review of Biochemistry, vol.57, issue.1, pp.443-478, 1988. ,
DOI : 10.1146/annurev.bi.57.070188.002303
Untangling the ErbB signalling network, Nature Reviews Molecular Cell Biology, vol.2, issue.2, pp.127-137, 2001. ,
DOI : 10.1038/35052073
EGFR and cancer prognosis, European Journal of Cancer, vol.37, issue.4, pp.9-15, 2001. ,
DOI : 10.1016/S0959-8049(01)00231-3
Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors, Oncogene, vol.19, issue.1, pp.24-31, 2009. ,
DOI : 10.1016/j.cell.2006.05.013
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial, and Paz-Ares, L. Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, pp.239-246, 2012. ,
DOI : 10.1016/S1470-2045(11)70393-X
Hyperactive Ras in developmental disorders and cancer, Nature Reviews Cancer, vol.91, issue.4, pp.295-308, 2007. ,
DOI : 10.1038/nrc2109
Methods of detection of mutation in human cancers], Bull Cancer, vol.86, pp.877-879, 1999. ,
Mutation Analysis of SLC26A4 for Pendred Syndrome and Nonsyndromic Hearing Loss by High-Resolution Melting, The Journal of Molecular Diagnostics, vol.13, issue.4, pp.416-426, 2011. ,
DOI : 10.1016/j.jmoldx.2011.03.003
A panel of high resolution melting (HRM) technology-based assays with direct sequencing possibility for effective mutation screening of EGFR and K-ras genes, Cell Oncol, vol.31, pp.329-333, 2009. ,
A multicenter blinded study evaluating EGFR and KRAS mutation testing methodologies in the clinical non-small cell lung cancer setting -IFCT) platforms, ERMETIC2 project Part 1 -Comparison of testing methods in 20 French Molecular Genetic National Cancer Institute ,
Mutation analysis of BRAF exon 15 and KRAS codons 12 and 13 in Moroccan patients with colorectal cancer, The International Journal of Biological Markers, vol.25, 2010. ,
DOI : 10.5301/JBM.2010.6091
Multiplicity and heterogeneity of molecular changes as a potential source of resistance to epidermal growth factor receptor -tyrosine kinase inhibitors (EGFR-TKI) in non-small cell lung cancer, Clin Cancer Res ,
High-resolution DNA melting analysis: advancements and limitations, Human Mutation, vol.64, issue.6, pp.857-859, 2009. ,
DOI : 10.1002/humu.20951
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments, Clinical Chemistry, vol.55, issue.4, pp.611-622, 2009. ,
DOI : 10.1373/clinchem.2008.112797
Polymorphisms in the epidermal growth factor receptor gene and the risk of primary lung cancer: a case-control study, BMC Cancer, vol.110, issue.1, p.199, 2007. ,
DOI : 10.1007/s00439-001-0656-4
Somatic mutations of epidermal growth factor receptor signaling pathway in lung cancers, International Journal of Cancer, vol.4, issue.2, pp.257-262, 2006. ,
DOI : 10.1002/ijc.21496
Comparative Screening of K-ras Mutations in Colorectal Cancer and Lung Cancer Patients Using a Novel Real-Time PCR with ADx-K-ras Kit and Sanger DNA Sequencing, Cell Biochemistry and Biophysics, vol.12, issue.3, pp.415-420 ,
DOI : 10.1007/s12013-011-9318-x
Technical considerations for KRAS testing in colorectal cancer. The biologist's point of view], Bull Cancer, vol.96, pp.47-56, 2009. ,
Assessing high-resolution melt curve analysis for accurate detection of gene variants in complex DNA fragments, Human Mutation, vol.17, issue.6, pp.876-883, 2009. ,
DOI : 10.1002/humu.20919
Digital PCR, Proceedings of the National Academy of Sciences, vol.96, issue.16, pp.9236-9241, 1999. ,
DOI : 10.1073/pnas.96.16.9236
Copy number variation and selection during reprogramming to pluripotency, Nature, vol.26, issue.7336, pp.58-62, 2011. ,
DOI : 10.1038/nature09871
Single-Molecule Detection of Epidermal Growth Factor Receptor Mutations in Plasma by Microfluidics Digital PCR in Non-Small Cell Lung Cancer Patients, Clinical Cancer Research, vol.15, issue.6, pp.2076-2084, 2009. ,
DOI : 10.1158/1078-0432.CCR-08-2622