50 a) Étude de l'expression du 50 b) Étude de l'effet du HPnc5490 sur le gène, 51 c) Implication du HPnc5490 dans la colonisation de l'estomac de souris par H. pylori, p.54 ,
55 a) Étude générale des cassettes aapA, Chapitre 2 : Études des cassettes, p.55 ,
Étude in vitro des cassettes : mécanisme d'interaction entre aapA, p.82 ,
94 a) Étude générale des aapA 94 b) Caractérisation des cassettes aapA, Chapitre, vol.2, p.97 ,
An Escherichia coli chromosomal "addiction module" regulated by guanosine [corrected] 3',5'-bispyrophosphate: a model for programmed bacterial cell death., Proceedings of the National Academy of Sciences, vol.93, issue.12, pp.6059-6063, 1996. ,
DOI : 10.1073/pnas.93.12.6059
Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori Development of inducible systems to engineer conditional mutants of essential genes of Helicobacter pylori, Nature Appl Environ Microbiol, vol.397, issue.74, pp.176-180, 1999. ,
Base pairing small RNAs and their roles in global regulatory networks, FEMS Microbiology Reviews, vol.34, issue.5, pp.866-882, 2010. ,
DOI : 10.1111/j.1574-6976.2010.00241.x
Development of Inducible Systems To Engineer Conditional Mutants of Essential Genes of Helicobacter pylori, Applied and Environmental Microbiology, vol.74, issue.7, pp.2095-2102, 2008. ,
DOI : 10.1128/AEM.01348-07
Escherichia coli RNA Degradosome, Biochem Soc Trans, vol.30, issue.2, pp.150-155, 2002. ,
DOI : 10.1016/S0076-6879(01)42556-0
cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors, Proceedings of the National Academy of Sciences, vol.93, issue.25, pp.14648-14653, 1996. ,
DOI : 10.1073/pnas.93.25.14648
The Helicobacter pylori Chemotaxis Receptor TlpB (HP0103) Is Required for pH Taxis and for Colonization of the Gastric Mucosa, Journal of Bacteriology, vol.188, issue.7, pp.2656-2665, 2006. ,
DOI : 10.1128/JB.188.7.2656-2665.2006
Helicobacter pylori??: notions fondamentales, ??pid??miologie, m??thodes diagnostiques, EMC - Gastro-ent??rologie, vol.5, issue.3, 2010. ,
DOI : 10.1016/S1155-1968(10)50083-X
Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk, Gut, vol.60, issue.9, pp.1189-95, 2011. ,
DOI : 10.1136/gut.2010.234468
Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli, PLoS Biology, vol.183, issue.2, p.1000317, 2010. ,
DOI : 10.1371/journal.pbio.1000317.s001
SOS Response Induces Persistence to Fluoroquinolones in Escherichia coli, PLoS Genetics, vol.178, issue.12, p.1000760, 2009. ,
DOI : 10.1371/journal.pgen.1000760.t001
Posttranscriptional Regulation of Flagellin Synthesis in Helicobacter pylori by the RpoN Chaperone HP0958, Journal of Bacteriology, vol.190, issue.24, pp.7975-84, 2008. ,
DOI : 10.1128/JB.00879-08
HIV-1 RNA Dimerization Initiation Site Is Structurally Similar to the Ribosomal A Site and Binds Aminoglycoside Antibiotics, Journal of Biological Chemistry, vol.278, issue.4, pp.2723-2730, 2003. ,
DOI : 10.1074/jbc.M205726200
Infection in the Absence of Antibodies and Is Mediated by MHC Class II???restricted Responses, The Journal of Experimental Medicine, vol.157, issue.12, pp.2277-2288, 1998. ,
DOI : 10.1073/pnas.95.4.1730
Immune responses of specificpathogen-free mice to chronic Helicobacter pylori (strain SS1) infection, Infect Immun, vol.66, pp.1349-1355, 1998. ,
Toxins-Antitoxins: Plasmid Maintenance, Programmed Cell Death, and Cell Cycle Arrest, Science, vol.301, p.1496, 2003. ,
The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair, Proceedings of the National Academy of Sciences, vol.106, issue.3, pp.894-899, 2009. ,
DOI : 10.1073/pnas.0808832106
Small Toxic Proteins and the Antisense RNAs That Repress Them, Microbiology and Molecular Biology Reviews, vol.72, issue.4, pp.579-589, 2008. ,
DOI : 10.1128/MMBR.00025-08
Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families, Nucleic Acids Research, vol.38, issue.11, pp.3743-3759, 2010. ,
DOI : 10.1093/nar/gkq054
Activation of gene expression by small RNA, Current Opinion in Microbiology, vol.12, issue.6, pp.674-682, 2009. ,
DOI : 10.1016/j.mib.2009.09.009
Stable inheritance of plasmid R1 requires two different loci, J Bacteriol, vol.161, pp.292-298, 1985. ,
Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells., Proceedings of the National Academy of Sciences, vol.83, issue.10, pp.3116-3120, 1986. ,
DOI : 10.1073/pnas.83.10.3116
Mechanism of post-segregational killing by the hoklsok system of plasmid R1: sok antisense RNA regulates formation of a hok mRNA species correlated with killing of plasmid-free cells, Molecular Microbiology, vol.14, issue.11, pp.1807-1818, 1990. ,
DOI : 10.1073/pnas.80.3.653
Prokaryotic toxin???antitoxin stress response loci, Nature Reviews Microbiology, vol.269, issue.5, pp.371-82, 2005. ,
DOI : 10.1016/S0092-8674(03)01034-1
The antisense RNA of the par locus of pAD1 regulates the expression of a 33-amino-acid toxic peptide by an unusual mechanism, Molecular Microbiology, vol.143, issue.3, pp.652-60, 2000. ,
DOI : 10.1046/j.1365-2958.2000.02035.x
Epithelial attachment alters the outcome of Helicobacter pylori infection, Proceedings of the National Academy of Sciences, vol.95, issue.7, pp.3925-3930, 1998. ,
DOI : 10.1073/pnas.95.7.3925
Escherichia coli mazEF-Mediated Cell Death Is Triggered by Various Stressful Conditions, Journal of Bacteriology, vol.186, issue.11, pp.3663-3672, 2004. ,
DOI : 10.1128/JB.186.11.3663-3669.2004
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC415763
A stable shuttle vector system for efficient genetic complementation of Helicobacter pylori strains by transformation and conjugation, Molecular and General Genetics MGG, vol.257, issue.5, 1998. ,
DOI : 10.1007/s004380050677
Natural transformation competence in Helicobacter pylori is mediated by the basic components of a type IV secretion system, Molecular Microbiology, vol.63, issue.2, pp.379-391, 2001. ,
DOI : 10.1046/j.1365-2958.2001.02502.x
Characterization of Helicobacter pylori factors that control transformation frequency and integration length during inter-strain DNA recombination, Molecular Microbiology, vol.141, issue.2, pp.387-401, 2011. ,
DOI : 10.1111/j.1365-2958.2010.07456.x
Peptide Antimicrobial Agents, Clinical Microbiology Reviews, vol.19, issue.3, pp.491-511, 2006. ,
DOI : 10.1128/CMR.00056-05
Lacking the HipBA Toxin-Antitoxin System during Prolonged Cultivation, Bioscience, Biotechnology, and Biochemistry, vol.258, issue.19, pp.117-123, 2009. ,
DOI : 10.1073/pnas.87.16.6181
Toxin-Antitoxin Systems in Escherichia coli Influence Biofilm Formation through YjgK (TabA) and Fimbriae, Journal of Bacteriology, vol.191, issue.4, pp.1258-1267, 2009. ,
DOI : 10.1128/JB.01465-08
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2632003
Progression of a loop-loop complex to a four-way junction is crucial for the activity of a regulatory antisense RNA, The EMBO Journal, vol.19, issue.21, pp.5905-5915, 2000. ,
DOI : 10.1093/emboj/19.21.5905
A Linear Pentapeptide Is a Quorum-Sensing Factor Required for mazEF-Mediated Cell Death in Escherichia coli, Science, vol.318, issue.5850, pp.652-657, 2007. ,
DOI : 10.1126/science.1147248
Persister cells, dormancy and infectious disease, Nature Reviews Microbiology, vol.71, issue.1, pp.48-56, 2005. ,
DOI : 10.1128/AAC.00684-06
UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION, The Lancet, vol.323, issue.8390, pp.1311-1316, 1984. ,
DOI : 10.1016/S0140-6736(84)91816-6
Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells., Journal of Bacteriology, vol.175, issue.18, pp.5899-5906, 1993. ,
DOI : 10.1128/jb.175.18.5899-5906.1993
Mutational Analysis of Metronidazole Resistance in Helicobacter pylori, Antimicrobial Agents and Chemotherapy, vol.49, issue.3, pp.1236-1243, 2005. ,
DOI : 10.1128/AAC.49.3.1236-1237.2005
Function, mechanism and regulation of bacterial ribonucleases, FEMS Microbiology Reviews, vol.23, issue.3, pp.371-90, 1999. ,
DOI : 10.1111/j.1574-6976.1999.tb00405.x
Specific and pleiotropic patterns of mRNA regulation by ArcZ, a conserved, Hfq-dependent small RNA, Molecular Microbiology, vol.50, issue.1, pp.139-58, 2009. ,
DOI : 10.1111/j.1365-2958.2009.06857.x
Regulatory RNA in Bacterial Pathogens, Cell Host & Microbe, vol.8, issue.1, pp.116-127, 2010. ,
DOI : 10.1016/j.chom.2010.06.008
URL : http://doi.org/10.1016/j.chom.2010.06.008
Multiple hok genes on the chromosome of Escherichia coli, Molecular Microbiology, vol.267, issue.5, pp.1090-1102, 1999. ,
DOI : 10.1146/annurev.ge.07.120173.001411
Evaluation of the Homologous Recombination in Helicobacter pylori, Helicobacter, vol.12, issue.3, pp.185-92, 2005. ,
DOI : 10.1128/IAI.71.9.5427-5431.2003
Small regulatory non-coding RNAs in bacteria: physiology and mechanistic aspects, Biology of the Cell, vol.17, issue.2, pp.117-131, 2009. ,
DOI : 10.1042/BC20070137
Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis., Journal of Clinical Investigation, vol.102, issue.8, pp.1506-1514, 1998. ,
DOI : 10.1172/JCI2808
Regulation of transcription in Helicobacter pylori: simple systems or complex circuits?, International Journal of Medical Microbiology, vol.291, issue.2, pp.107-117, 2001. ,
DOI : 10.1078/1438-4221-00107
The role of internal urease in acid resistance of Helicobacter pylori, Gastroenterology, vol.114, issue.1, pp.58-70, 1998. ,
DOI : 10.1016/S0016-5085(98)70633-X
Global RNA Half-Life Analysis in Escherichia coli Reveals Positional Patterns of Transcript Degradation, Genome Research, vol.13, issue.2, pp.216-223, 2003. ,
DOI : 10.1101/gr.912603
From ???carpet??? mechanism to de-novo designed diastereomeric cell-selective antimicrobial peptides, Peptides, vol.22, issue.10, pp.1629-1641, 2001. ,
DOI : 10.1016/S0196-9781(01)00498-3
The primary transcriptome of the major human pathogen Helicobacter pylori, Nature, vol.73, issue.7286, pp.250-255, 2010. ,
DOI : 10.1038/nature08756
An SOS-Regulated Type 2 Toxin-Antitoxin System, Journal of Bacteriology, vol.191, issue.24, pp.7456-65, 2009. ,
DOI : 10.1128/JB.00963-09
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2786605
Natural transformation in Helicobacter pylori: DNA transport in an unexpected way, Trends in Microbiology, vol.10, issue.4, pp.159-162, 2002. ,
DOI : 10.1016/S0966-842X(02)02314-4
Evidences of autoregulation of hfq expression in Sinorhizobium meliloti strain 2011, Archives of Microbiology, vol.34, issue.2, pp.629-668, 2011. ,
DOI : 10.1007/s00203-011-0701-1
Small RNAs as regulators of primary and secondary metabolism in Pseudomonas species, Applied Microbiology and Biotechnology, vol.16, issue.1, pp.63-79, 2011. ,
DOI : 10.1007/s00253-011-3332-1
Prokaryotic transcriptomics: a new view on regulation, physiology and pathogenicity, Nature Reviews Genetics, vol.290, issue.1, pp.9-16, 2010. ,
DOI : 10.1038/nrg2695
Acid survival of Helicobacter pylori: how does urease activity trigger cytoplasmic pH homeostasis?, Trends in Microbiology, vol.10, issue.2, pp.70-74, 2002. ,
DOI : 10.1016/S0966-842X(01)02287-9
Channel-mediated potassium uptake in Helicobacter pylori is essential for gastric colonization, The EMBO Journal, vol.17, issue.1, pp.232-241, 2007. ,
DOI : 10.1038/sj.emboj.7601471
AN ABUNDANCE OF RNA REGULATORS, Annual Review of Biochemistry, vol.74, issue.1, pp.199-217, 2005. ,
DOI : 10.1146/annurev.biochem.74.082803.133136
The complete genome sequence of the gastric pathogen Helicobacter pylori, Nature, vol.388, issue.6642, pp.539-547, 1997. ,
DOI : 10.1038/41483
A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli, Molecular Microbiology, vol.279, issue.1, pp.258-70, 2008. ,
DOI : 10.1111/j.1365-2958.2008.06416.x
The bacterial Sm-like protein Hfq: a key player in RNA transactions, Molecular Microbiology, vol.7, issue.0, pp.1525-1533, 2004. ,
DOI : 10.1111/j.1365-2958.2003.03935.x
Toxin???antitoxin systems: why so many, what for?, Current Opinion in Microbiology, vol.13, issue.6, pp.781-785, 2010. ,
DOI : 10.1016/j.mib.2010.10.006
Gene expression patterns during swarming in Salmonella typhimurium: genes specific to surface growth and putative new motility and pathogenicity genes, Molecular Microbiology, vol.3, issue.1, pp.169-87, 2004. ,
DOI : 10.1111/j.1365-2958.2003.03977.x
Helicobacter pylori and Gastric Cancer: Factors That Modulate Disease Risk, Clinical Microbiology Reviews, vol.23, issue.4, pp.713-752, 2010. ,
DOI : 10.1128/CMR.00011-10
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2952980
Outer Membrane Vesicles of Helicobacter pylori TK1402 are Involved in Biofilm Formation, BMC Microbiology, vol.9, issue.1, p.197, 2009. ,
DOI : 10.1186/1471-2180-9-197
Assessment of in vitro biofilm formation by Helicobacter pylori, Journal of Gastroenterology and Hepatology, vol.12, issue.1, pp.90-94, 2010. ,
DOI : 10.1111/j.1440-1746.2009.06213.x